{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:11:12Z","timestamp":1773418272329,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Emicizumab has proven to be a turning point in the management of patients with Haemophilia A (HA). In resource\u2010limited settings, data on low\u2010dose emicizumab prophylaxis (LDEP) in HA patients are emerging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010seven patients previously on factor FVIII prophylaxis or bypassing agents (BPAs) received LDEP at a dose of 3\u2010mg\/kg SC for 4 weeks, followed by 1.5\u2010mg\/kg SC every 2 weeks. The primary objective was to assess the efficacy of LDEP measured in the form of reduction in annualised bleed rates (ABR), treated joint bleed and conversion of target joint to non\u2010target joint. The secondary objectives were to study the improvement in joint scores (HJHS and FISH score) and to assess quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median duration of LDEP was 15 months. On LDEP, the mean ABR was 0.41 \u00b1 0.7 (median = 0; IQR: 0\u20130.6). Sixty\u2010seven percent of patients had zero bleeds, and 66% of target joints converted to non\u2010target joints. There was a significant improvement in HJHS, FISH and QoL in patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDEP, although not optimal, remains an effective strategy in the prevention of bleeds, improvement of QOL and reduction of joint\u2010related disability in HA patients in resource\u2010constrained settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70211","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:29:40Z","timestamp":1768807780000},"page":"453-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging the Gap: Efficacy of Low\u2010Dose Emicizumab in Haemophilia A With or Without Inhibitors"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6842-8613","authenticated-orcid":false,"given":"Gaurav","family":"Datta","sequence":"first","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra Prasad","family":"Verma","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swasti","family":"Sinha","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchira","family":"Mukherji","sequence":"additional","affiliation":[{"name":"Army Institute of Cardio\u2010Thoracic Sciences  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghuveer","family":"Punuru","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritra","family":"Saha","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Middinti","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajkumar","family":"Maurya","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpika","family":"Shukla","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Suri","sequence":"additional","affiliation":[{"name":"King George's Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Hemophilia A. 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