{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:39:53Z","timestamp":1787312393076,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited existing research on mental health and health\u2010related quality of life (HRQoL) in people with hemophilia (PwH) suggests these patients still may have poor mental health despite treatment advances significantly improving somatic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This multicenter study aimed to systematically assess mental health and HRQoL and their association with disease severity, age and treatment regimen among PwH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study, conducted in nine Swiss hemophilia treatment centers, included participants aged six years and older with congenital hemophilia of any severity. The study procedure comprised a semi\u2010structured psychiatric diagnostic interview and an online survey comprising age\u2010validated psychological measures to capture mental health and HRQoL. Treatment centers provided clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 164 PwH enrolled in the study, 156 participants completed the psychiatric diagnostic interview. 25% met the criteria for a mental disorder (MD). Most common among the MD were affective disorders, substance use disorders, and attention deficit hyperactive disorder. Moderate\/severe hemophilia and lower baseline factor activity were significantly associated with higher psychopathology and lower HRQoL. Of participants with moderate\/severe hemophilia, 26% of those on prophylaxis versus 45% of those on on\u2010demand met the criteria for an MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated prevalence of MD, and the association of psychopathology with disease severity and treatment regimen, highlights the continued relevance of mental health in hemophilia research. Further objective clinical research is indispensable to define targets for improved and individualized comprehensive treatment care plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Major treatment advances have transformed hemophilia care, allowing most people with hemophilia (PwH) to have average lifespans. Reduced bleeding complications have shifted attention to overall well\u2010being and mental health of PwH. The multicenter Swiss HERMES study examined 164 children and adults with hemophilia to explore the link between disease severity, treatment regimen, mental health, and health\u2010related quality of life using standard questionnaires and a psychiatric interview. About one in four participants had at least one mental disorder\u2014most often depression, substance use disorders, or ADHD. Participants with moderate or severe hemophilia, or lower clotting factor levels, reported poorer health\u2010related quality of life. Prophylactic treatment may support mental health in participants with moderate or severe hemophilia. These findings show that mental health issues are common in PwH and highlight the need to integrate psychological screening and support into comprehensive hemophilia care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70219","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:14:22Z","timestamp":1769768062000},"page":"748-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemophilia Severity and Its Association With Mental Health and Health\u2010Related Quality of Life\u2014Results From a Cross\u2010Sectional Multicenter Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Francesca","family":"Schmitt","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Department of Pediatrics Inselspital University Hospital University of Bern  Bern Switzerland"},{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Maier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Department of Pediatrics Inselspital University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lerch","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Albisetti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology University Children`s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Trinchero","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Graf","sequence":"additional","affiliation":[{"name":"Center For Laboratory Medicine and Hemophilia Hemostasis Center  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Division of Oncology\/ Hematology Children's Hospital of Eastern Switzerland  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Angiology and Hemostasis University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas von der","family":"Weid","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University Children's Hospital Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Scheinemann","sequence":"additional","affiliation":[{"name":"Division of Oncology\/ Hematology Children's Hospital of Eastern Switzerland  St. Gallen Switzerland"},{"name":"Faculty of Health Sciences and Medicine University Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"von Mackensen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Reichl","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Cavelti","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"M\u00fcrner\u2010Lavanchy","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"Faculty of Psychology University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna A. 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