{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:27Z","timestamp":1781513727092,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Magnetic resonance imaging (MRI) is the gold standard for assessing haemophilic arthropathy using the IPSG scale. However, MRI\u2010detected abnormalities often correlate poorly with pain, suggesting that structural damage alone cannot explain symptoms. Assessing additional features such as bone marrow oedema (BME) may better capture disease activity and pain in people with haemophilia (PwH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the presence and extent of bone BME in the ankles of PwH, assess the reproducibility of MRI scoring for BME and IPSG, and examine correlations between MRI findings, clinical parameters, pain, and ultrasound results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study was conducted on 56 PwH, assessing 108 ankle joints via MRI using a 3T scanner. IPSG and BME scores were independently assessed by two blinded radiologists. Statistical analyses assessed inter\u2010reader agreement, correlations between MRI scores, and their associations with ultrasound (HEAD\u2010US), joint health (HJHS), and pain intensity over the past 24 h and 4 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BME was observed in 45% of left and 34% of right ankles. Both IPSG and BME scores showed high reproducibility. BME scores correlated strongly with pain (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.61\u20130.68) and moderately with joint health (HJHS,\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.56), whereas IPSG total scores showed moderate correlations with pain (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.46\u20130.51). Resampling analyses confirmed stronger BME\u2010pain associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that BME is common in haemophilic ankles and more strongly associated with pain and joint health than IPSG scores. Integrating BME into MRI assessments may enhance evaluation and monitoring of haemophilic joint disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70221","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:34:51Z","timestamp":1770273291000},"page":"809-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Surface: Bone Marrow Oedema as a Hidden Marker of Pain in Haemophilic Ankles"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"first","affiliation":[{"name":"Haemostasis and Thrombosis Unit, Division of Haematology Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Service D'ergoth\u00e9rapie Et De Kin\u00e9sith\u00e9rapie Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Neuromusculoskeletal Lab (NMSK), Secteur des Sciences de La Sant\u00e9, Institut de Recherche Exp\u00e9rimentale Et Clinique Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Institut De Recherche Exp\u00e9rimentale &amp; 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Clinique (IREC) \u2013 Department of Radiology Universit\u00e9 Catholique de Louvain (UCLouvain) \u2013 Cliniques Universitaires Saint Luc  Brussels Belgium"},{"name":"Department of Radiology Centre Hospitalier de L'universit\u00e9 De Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9026","authenticated-orcid":false,"given":"Anthe","family":"Foubert","sequence":"additional","affiliation":[{"name":"Research Group (MOVANT), Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Pain in Motion International Research Group  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokmane","family":"Taihi","sequence":"additional","affiliation":[{"name":"Institut De Recherche Exp\u00e9rimentale &amp; Clinique (IREC) \u2013 Department of Radiology Universit\u00e9 Catholique de Louvain (UCLouvain) \u2013 Cliniques Universitaires Saint Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kirchgesner","sequence":"additional","affiliation":[{"name":"Institut De Recherche Exp\u00e9rimentale &amp; 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