{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:03:18Z","timestamp":1776340998148,"version":"3.51.2"},"reference-count":94,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Traditional haemophilia therapies act to replace the relevant missing clotting factor, are not interchangeable between haemophilia A and B and cannot be used in patients with high titre inhibitors. Novel non\u2010replacement factor therapies (NFT) target other endogenous coagulation proteins or anticoagulants such as antithrombin (AT) and tissue factor pathway inhibitor (TFPI) to rebalance haemostasis. As such, pharmaceutical clinical trials of these molecules have enrolled patients with haemophilia A or B, with and without inhibitors. The requirement for monitoring the efficacy of NFTs is greatly reduced compared to replacement therapy and global assays such as thrombin generation assay (TGA) have been used extensively in clinical trials to indicate improvement to haemostasis.<\/jats:p>\n                    <jats:p>Comprehensive haemophilia care, including access to and laboratory monitoring of replacement and NFTs, is well established in high income countries, but there are profound global inequities in the diagnosis and treatment of haemophilia which still need to be remedied. The authors examine the challenges of haemophilia and von Willebrand diagnosis and monitoring of NFTs using conventional and global assays of haemostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70224","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:20:53Z","timestamp":1776338453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Practical Advances in the Diagnosis of Haemophilia and von Willebrand Disease Including Monitoring of Non\u2010Factor Replacement Therapies"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-5848","authenticated-orcid":false,"given":"Annette","family":"Bowyer","sequence":"first","affiliation":[{"name":"Department of Coagulation Royal Hallamshire Hospital  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-3765","authenticated-orcid":false,"given":"Silmara","family":"Montalv\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory Hemostasis and Thrombosis, Hematology and Hemotherapy Center University of Campinas UNICAMP  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-1463","authenticated-orcid":false,"given":"Yesim","family":"Dargaud","sequence":"additional","affiliation":[{"name":"French Reference Center for Haemophilia and Clinical Haemostasis Unit Louis Pradel Hospital  Lyon France"},{"name":"Faculty of Medicine Lyon Est UR4609 Research Laboratory on Haemophilia University Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2025.288245"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S490588"},{"key":"e_1_2_10_4_1","unstructured":"World Federation of Hemophilia.World Federation of Hemophilia. 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