{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:39Z","timestamp":1781513739008,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012112","name":"Swedish Orphan Biovitrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bleeding episodes can impair physical functioning and cause chronic pain in haemophilia A. The Haemophilia Quality of Life Questionnaire for Adults (Haem\u2010A\u2010QoL) was administered in XTEND\u20101; the Physical Health (PH) subscale evaluated Physical Health\/Functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate psychometric properties of Haem\u2010A\u2010QoL PH and estimate clinically meaningful change thresholds using XTEND\u20101 data (NCT04161495).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Previously treated patients (aged \u226512 years) with severe haemophilia A received once\u2010weekly efanesoctocog alfa prophylaxis (50\u00a0IU\/kg) for 52 weeks (Arm A; pre\u2010study prophylaxis), or on\u2010demand efanesoctocog alfa (50\u00a0IU\/kg) for 26 weeks followed by 26 weeks once\u2010weekly prophylaxis (Arm B; pre\u2010study on\u2010demand). Psychometric analyses used pooled data (Arms A and B) to confirm test\u2010retest reliability, construct validity, and responsiveness of the Haem\u2010A\u2010QoL PH and total scores. Clinically meaningful change thresholds were estimated using data from Arm A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Haem\u2010A\u2010QoL PH items were completed by all patients in the psychometric sample (\n                      <jats:italic>N<\/jats:italic>\n                      = 126) at baseline and 120 patients (95%) at Week 52. Haem\u2010A\u2010QoL PH and Haem\u2010A\u2010QoL total scores demonstrated high internal consistency reliability, construct validity, acceptable test\u2010retest reliability, responsiveness, and discriminated between known groups at baseline and Week 52. The meaningful within\u2010patient change (MWPC) threshold estimate was \u221210.0 (range \u221215.0 to \u22128.7) for Haem\u2010A\u2010QoL PH and \u22128.5 (\u22128.5 to \u22124.6) for Haem\u2010A\u2010QoL total scores (using PGIS\u2010Joint). Respective proposed meaningful within\u2010group improvement thresholds were \u22126.8 (range \u22124.8 to \u22126.8) and \u22125.8 (\u22125.8 to \u22123.5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Haem\u2010A\u2010QoL PH is a reliable, valid, and responsive measure to assess the impact of interventions in the treatment of haemophilia A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70233","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:54:19Z","timestamp":1773003259000},"page":"699-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Psychometric Analysis of the Haemophilia Quality of Life Questionnaire for Adults Physical Health Subscale and Total Scores: Data From the Phase 3 XTEND\u20101 Trial in Patients With Severe Haemophilia A"],"prefix":"10.1111","volume":"32","author":[{"given":"J\u00e9r\u00f4me","family":"Msihid","sequence":"first","affiliation":[{"name":"Sanofi  Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods Evidence, and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wilson","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Kragh","sequence":"additional","affiliation":[{"name":"Sobi  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Nelson","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina 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