{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:33Z","timestamp":1781513733843,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012112","name":"Swedish Orphan Biovitrum","doi-asserted-by":"publisher","award":["NP\u201031820"],"award-info":[{"award-number":["NP\u201031820"]}],"id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Joint bleeds are burdensome and recovery differs from bleed to bleed. Identifying predictors of recovery could enable personalized treatment and monitoring; aiming to prevent long\u2010term joint deterioration, and facilitate faster return to activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify predictors of time to recovery after joint bleeding in people with haemophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regular care data on recovery of joint bleeds were collected from people with haemophilia who attended the Van Creveldkliniek between 2016 and 2025. The primary outcome was time to recovery, defined as the normalization of all clinical symptoms. Kaplan\u2013Meier survival curves and Cox proportional hazard regression were conducted. Independent variables were as follows: trough level, joint status, cause of the bleed, joint location, limitation in ROM, effusion on ultrasound, time between start of symptoms and start of treatment, treatment days and emicizumab treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010four bleeds in 44 individuals were included. Most of the patients had haemophilia A (87.9%). Median time to recovery was 32.5 days. Joint bleeds without limitation in range of motion (&lt;15 degrees limitation in flexion or extension) at presentation recovered 2.3 times faster (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007) than bleeds with a limitation. Patients with severe haemophilia A on emicizumab prophylaxis recovered 2.7 times faster than those on factor\u2010prophylaxis (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Joint bleeds with significant limitation in ROM at presentation needed more time to recover. Patients with severe haemophilia on emicizumab showed shorter recovery after joint bleeding. Follow\u2010up should be personalized and extended beyond one month.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70234","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:09:29Z","timestamp":1772971769000},"page":"691-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Recovery After Joint Bleeding in Persons With Bleeding Disorders"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3313-0671","authenticated-orcid":false,"given":"Gijs","family":"Aertssen","sequence":"first","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-5524","authenticated-orcid":false,"given":"Lize F. D.","family":"van Vulpen","sequence":"additional","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-8555","authenticated-orcid":false,"given":"Wouter","family":"Foppen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-4385","authenticated-orcid":false,"given":"Flora H. P.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-999X","authenticated-orcid":false,"given":"Merel A.","family":"Timmer","sequence":"additional","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1756188"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14791"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2008.07386.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.032"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001238"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_13_8_1","volume-title":"Richtlijn Diagnostiek en Behandeling van Hemofilie en Aanverwante Hemostasestoornissen","author":"NVHB","year":"2009"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12\u201011\u20100874"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12690"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15065"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010198006000\u201000018"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40634\u2010018\u20100161\u20105"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1785525"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2025.102717"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100173"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.04.010"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209226"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70234","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:24:37Z","timestamp":1781511877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/hae.70234"],"URL":"https:\/\/doi.org\/10.1111\/hae.70234","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}