{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:18Z","timestamp":1781513718778,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Clotting factor prophylaxis remains the most prescribed standard\u2010of\u2010care treatment for people with haemophilia (PwH). Prophylaxis prevents bleeds, joint damage, and improves quality of life (QoL). Its success depends on treatment adherence, consisting of socioeconomic, behavioural, and disease\u2010 or therapy\u2010related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify determinants of clotting factor prophylaxis adherence among PwH followed at a Hemophilia Treatment Center (HTC) in Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted at a Brazilian HTC in June\u2013October\/2022. Eligible participants were PwH A or B without inhibitors and on clotting factor prophylaxis, aged \u2265 14 years. Demographic, clinical, and therapeutic data were collected from records and interviews. Health\u2010related QoL was assessed by the SF\u201036 questionnaire. Adherence was assessed using the Brazilian validated Validated Hemophilia Regimen Treatment Adherence Scale\u2010Prophylaxis (VERITAS\u2010Pro) questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 78 PwH (median age 30 years), 70 (90%) had severe haemophilia, 46 (59%) reported joint impairment, and 67 (86%) infused 3 times\/week. Median SF\u201036 score was 70.3 (interquartile range [IQR] 57.3\u201383.3). Median VERITAS\u2010Pro score was 44.0 (IQR 35.0\u201350.0), resulting in 70 (90%) adherent PwH. SF\u201036 score was not correlated with VERITAS\u2010Pro. Clotting factor prophylaxis adherence was associated with having haemophilia A (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012) and infusing factor &gt;2 times weekly (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008), and inversely correlated with prophylaxis duration (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.317 [weak clinical correlation];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), and directly correlated with SF\u201036 domain \u201cMental health\u201d (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.304 [weak clinical correlation];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The main factors determining adherence to clotting factor prophylaxis were having haemophilia A, receiving factor infusions more than twice weekly, having a shorter duration of prophylaxis, and good mental health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70244","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:59:43Z","timestamp":1774263583000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adherence to Clotting Factor Prophylaxis in Adolescent and Adult Males With Haemophilia"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-1480","authenticated-orcid":false,"given":"Nath\u00e1lia Martins","family":"Beserra","sequence":"first","affiliation":[{"name":"Centro de Hematologia e Hemoterapia do Cear\u00e1 (HEMOCE)  Fortaleza 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