{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:07:29Z","timestamp":1784300849026,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Haemophilia care varies across economic settings, influencing diagnosis, treatment and outcomes. The World Bleeding Disorders Registry (WBDR) enables standardized, patient\u2010level global benchmarking. We present the first multicentre analysis of Indian persons with haemophilia (PwH) in the WBDR, enabling robust benchmarking against regional and income\u2010stratified global cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study analysed de\u2010identified WBDR data from six haemophilia treatment centres in India across geographic areas. Standardized demographic, clinical, and treatment indicators were benchmarked against South\u2010East Asia (SEA), income\u2010stratified global WBDR cohorts, and World Federation of Hemophilia Annual Global Survey (WFH AGS) 2023 data, focusing on diagnosis, severity, treatment, functional status, inhibitor status and employment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1,780 PwH (86% haemophilia A), 77% had severe disease. Median age was 20 years (IQR 11\u201331), significantly younger than global WBDR and AGS cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Median age at diagnosis for severe haemophilia was 60 months (IQR 12180), markedly later than in upper\u2010middle\u2010 and high\u2010income countries (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 10\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>5<\/jats:sup>\n                      ). Only 7% of severe PwH received prophylaxis compared with &gt;60% in high\u2010income settings, higher ABR (median 6\u00a0vs 01) and greater target\u2010joint prevalence (31%\u00a0vs 9%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Among adults, 62% were employed, comparable to other lower\u2010middle\u2010income countries. Inhibitor surveillance was limited: 2% of severe PwH were tested in the prior 12 months, while lifetime inhibitor prevalence was 14%, similar to regional LMIC cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Indian WBDR data underscore the value of registry participation for meaningful benchmarking of haemophilia care, highlighting progress in diagnosis and employment outcomes alongside clear opportunities to expand treatment coverage and improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70255","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:34:16Z","timestamp":1773077656000},"page":"905-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haemophilia Care in India: A Multicentre Cross\u2010Sectional Analysis From the World Bleeding Disorders Registry Benchmarking Across Global Gross National Income Strata"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-5641","authenticated-orcid":false,"given":"Nita","family":"Radhakrishnan","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Oncology Post Graduate Institute of Child Health  Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-7332","authenticated-orcid":false,"given":"M. Joseph","family":"John","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, Haemato\u2010Oncology and Bone Marrow (Stem Cell) Transplantation Christian Medical College  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-5123","authenticated-orcid":false,"given":"Emily","family":"Ayoub","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ticiana","family":"Pereira","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-5196","authenticated-orcid":false,"given":"Anupam","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Medicine Assam Medical College and Hospital  Dibrugarh Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-5053","authenticated-orcid":false,"given":"Sreejith","family":"Govindan","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, and Hemophilia Society Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Sidharthan","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Amrita Institute of Medical Sciences  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chepsy C.","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Believers Church Medical College Hospital  Tiruvalla Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-4017","authenticated-orcid":false,"given":"Archit","family":"Pandharipande","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology Post Graduate Institute of Child Health  Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6760-6618","authenticated-orcid":false,"given":"Damanpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, Haemato\u2010Oncology and Bone Marrow (Stem Cell) Transplantation Christian Medical College  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6817-4812","authenticated-orcid":false,"given":"Harshal","family":"Kale","sequence":"additional","affiliation":[{"name":"Regional Program Manager, South Asia and East Asia World Federation of Hemophilia  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Coffin","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201010\u2010675140"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14012"},{"key":"e_1_2_13_5_1","unstructured":"World Federation of Hemophilia. Report on the Annual Global Survey 2023. Montr\u00e9al (Canada): World Federation of Hemophilia; 2024: [Accessed 10 October 2025] https:\/\/wfh.org\/research\u2010and\u2010data\u2010collection\/annual\u2010global\u2010survey\/."},{"key":"e_1_2_13_6_1","unstructured":"World Federation of Hemophilia. World Bleeding Disorders Registry (WBDR) Data Dashboard. Accessed 11 Jan 2026 https:\/\/wfh.org\/research\u2010and\u2010data\u2010collection\/world\u2010bleeding\u2010disorders\u2010registry\/wbdr\u2010data\u2010dashboard\/."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102264"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010015\u20100562\u2010x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018GS112562"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13425"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100061"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537\u20102995.1995.35795357875.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010052358"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14496"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049\u20103848(10)70150\u2010X"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20108652(199812)59:4<288::aid\u2010ajh4>3.0.co;2\u2010i"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6905a1"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2010.02318.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.59556\/japi.73.1055"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101066024"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010018\u20101059\u20101"},{"issue":"7","key":"e_1_2_13_23_1","first-page":"559","article-title":"Comprehensive Hemophilia Management in India\u2014Miles to Go Before We Sleep","volume":"55","author":"Bansal D.","year":"2018","journal-title":"Indian Pediatrics"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpgm.JPGM_701_16"},{"key":"e_1_2_13_25_1","unstructured":"Ministry of Statistics and Programme Implementation. Periodic Labour Force Survey (PLFS) 2023\u201324: Annual Report. Government of India September 2024. Available at: (Accessed 21 October 2025) https:\/\/www.pib.gov.in\/PressReleaseIframePage.aspx?PRID=2120359."},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.12.029"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:45:27Z","timestamp":1784299527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hae.70255"],"URL":"https:\/\/doi.org\/10.1111\/hae.70255","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}