{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:39Z","timestamp":1781513739052,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The therapeutic landscape for patients with haemophilia A (PwHA) is rapidly evolving with the introduction of extended half\u2010life FVIII (EHL\u2010FVIII) and non\u2010FVIII therapies that mimic FVIII, such as emicizumab (EMI). Monitoring non\u2010factor therapies in the laboratory poses challenges; however, the thrombin generation assay (TGA) can be utilized to evaluate hemostatic capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the endogenous thrombin potential (ETP) and peak thrombin (PT) in pediatric patients with moderate to severe haemophilia A (SHA) undergoing EHL\u2010FVIII therapies and EMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Platelet\u2010poor plasma (PPP) from PwHA on EHL\u2010FVIII or EMI prophylaxis was tested on the calibrated automated thrombogram (CAT) using PPP low reagent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ETP and PT were significantly higher in the EHL\u2010FVIII group compared to the EMI group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pediatric patients on EHL\u2010FVIII prophylaxis demonstrated higher ETP in vitro using PPP compared to those on EMI prophylaxis. These findings highlight the need for further systematic investigations to explore the implications of these differences in bleed control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70258","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:25:43Z","timestamp":1773339943000},"page":"834-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thrombin Generation in Pediatric Haemophilia A Patients on Extended Half\u2010Life FVIII versus Non\u2010FVIII Therapies"],"prefix":"10.1111","volume":"32","author":[{"given":"Jessica","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean G.","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Young","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Center, Cancer and Blood Diseases Institute, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Zia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201001\u2010528414"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.01.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2010.03767.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.12.007"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071636"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1717114"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14359"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1649378"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703068"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001869"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803550"},{"issue":"8","key":"e_1_2_12_14_1","article-title":"Serious Bleeds in Pediatric Hemophilia A Patients on Emicizumab Prophylaxis","volume":"7","author":"Garcia J.","journal-title":"2023: Research and Practice in Thrombosis and Haemostasis (In press)"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27039"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194303"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14679"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14213"},{"key":"e_1_2_12_19_1","article-title":"Laboratory Monitoring in Patients Receiving Emicizumab","author":"Muller J.","year":"2025","journal-title":"Hamostaseologie"},{"key":"e_1_2_12_20_1","unstructured":"S. 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