{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:21Z","timestamp":1781513721902,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Children with haemophilia (CwH) may show reduced muscle strength due to recurrent haemarthroses and disuse. Despite prophylaxis, data on strength profiles in modern\u2010treated paediatric populations are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of the current study was to evaluate the influence of haemophilia on muscle strength in children and adolescents, adjusting for age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials<\/jats:title>\n                    <jats:p>Thirty\u2010four boys with haemophilia (mean age = 12.0 years) on prophylaxis and 25 age\u2010matched healthy male controls (mean age = 11.3 years) underwent isometric dynamometry of bilateral elbow and knee flexion\/extension using a MicroFet2 device. Eight strength variables were analyzed via general linear model (GLM) with age as covariate and group as factor, followed by regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Strength correlated strongly with age (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.68\u20130.87,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The GLM showed significant main effects of age (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006). Univariate tests revealed lower strength in CwH for left\u2010knee flexion (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040) and extension (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007). Regression indicated an age\u2010adjusted penalty of \u221217.9 N for left\u2010knee flexion and \u221226.6 N for extension (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036 and 0.015, respectively). Differences narrowed with age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CwH display reduced isometric knee strength\u2014particularly in the non\u2010dominant limb\u2014despite prophylaxis. Early, individualized physiotherapy and regular strength monitoring are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70280","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:23:34Z","timestamp":1776054214000},"page":"829-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscle Strength in Children and Adolescents With Haemophilia on Prophylaxis: An Age\u2010Adjusted Dynamometric Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Dimitrios","family":"Syrengelas","sequence":"first","affiliation":[{"name":"Department of Pediatric Physical Therapy \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"School of Medicine Faculty of Health Sciences National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Michalopoulou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\/Haemostasis and Thrombosis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Dettoraki","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\/Haemostasis and Thrombosis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis","family":"Kyprianou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\/Haemostasis and Thrombosis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kosmopoulos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Physical Therapy \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Skarpelos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Physical Therapy \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Papakonstantinou","sequence":"additional","affiliation":[{"name":"Second Department of Radiology Attikon General University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Pergantou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\/Haemostasis and Thrombosis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01575"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13455"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15149"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2020.0016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/s24061861"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01354.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011180.pub2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15067"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2020.04.010"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718784834"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1310-82"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.13119"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/12.5.381"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00575.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:21:05Z","timestamp":1781511665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,12]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/hae.70280"],"URL":"https:\/\/doi.org\/10.1111\/hae.70280","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,12]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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