{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:05:17Z","timestamp":1789751117373,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Women with haemophilia can present manifestations and experience undiagnosed symptoms, which negatively affect their health\u2010related quality of life (HRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the HRQoL in obligate carriers of haemophilia (OCH) versus women non\u2010carriers of haemophilia (WNCH) in a Colombian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational, cross\u2010sectional study of women over 18 years. OCH were defined as daughters of a father with haemophilia, mothers of two or more sons with haemophilia, or mothers of one son with haemophilia and another affected relative. OCH were matched 1:1 with WNCH according to socioeconomic stratum and age. Women with other haematological pathologies, use of anticoagulants or antiplatelets, pregnancy or cognitive impairment were excluded. The Bleeding Assessment Tool (ISTH\u2010BAT) was used to evaluate bleeding symptoms, and the SF\u201036 questionnaire was used to measure HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 104 women were included (52 OCH and 52 WNCH), with a median age of 49 years (IQR 40.5\u201348.5). WNCH had higher educational levels and a lower proportion of homemakers (23.8%\u00a0vs. 46.15%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015). A total of 38.46% had abnormal bleeding (ISTH\u2010BAT \u2265 6), which was more frequent in OCH (75%\u00a0vs. 1.92%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), with menorrhagia being the most prevalent manifestation (90.38%\u00a0vs. 44.23%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). OCH reported lower scores in all of the SF\u201036 domains, with greater involvement in physical role (65.38%), while the WNCH reported a lower score in mental health (17.31%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with WNCH, OCH have a significantly more compromised HRQoL, which highlights the need for specific interventions to improve their physical and psychosocial well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70282","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:34:52Z","timestamp":1778664892000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health\u2010Related Quality of Life Among Female Carriers of Haemophilia and Non\u2010Carriers in a Colombian Population"],"prefix":"10.1111","volume":"32","author":[{"given":"Fabian A.","family":"Manzano\u2010Di Zeo","sequence":"first","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sossa\u2010Melo","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander\u2010 FOSCAL  Floridablanca Colombia"},{"name":"Programa Para El Tratamiento de Enfermedades Hemato\u2010Oncol\u00f3gicas De Santander PROTEHOS  Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Luna\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"},{"name":"Programa Para El Tratamiento de Enfermedades Hemato\u2010Oncol\u00f3gicas De Santander PROTEHOS  Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ochoa\u2010Vera","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Tarazona\u2010Boh\u00f3rquez","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Salazar\u2010Monta\u00f1a","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"},{"name":"Programa Para El Tratamiento de Enfermedades Hemato\u2010Oncol\u00f3gicas De Santander PROTEHOS  Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"S\u00e1nchez\u2010Sossa","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherinee","family":"Morales\u2010Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander\u2010 FOSCAL  Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Rey\u2010Serrano","sequence":"additional","affiliation":[{"name":"Facultad De Ciencias De La Salud Universidad Aut\u00f3noma de Bucaramanga \u2010 UNAB  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Pe\u00f1a\u2010Castellanos","sequence":"additional","affiliation":[{"name":"Programa Para El Tratamiento de Enfermedades Hemato\u2010Oncol\u00f3gicas De Santander PROTEHOS  Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Federation of Hemophilia Women and Girls With Hemophilia Montr\u00e9al; 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