{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:07:26Z","timestamp":1784300846379,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Efanesoctocog alfa (EFA) is an ultra\u2013extended half\u2010life factor VIII (FVIII) developed to address limitations of conventional prophylaxis in haemophilia A. Although the XTEND trials reported low interindividual pharmacokinetic (PK) variability, real\u2010world data remain important to better characterize PK profiles across patient subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To report real\u2010world PK data for EFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010centre study, adults and children (&gt;6 years) with severe haemophilia A at Strasbourg University Hospital switched from a prior FVIII product to EFA. A simplified PK assessment was performed once or twice per patient after a 50\u00a0IU\/kg infusion. FVIII activity was measured pre\u2010infusion and at 3, 24, 96 h, and 7 days post\u2010infusion. Patients were reassessed at steady state after \u22656 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In adults, mean (range) half\u2010life was 52 h (35\u201362). Mean incremental recovery at 3 h was 2.98\u00a0IU\/dL per IU\/kg (1.85\u20133.82). Mean FVIII trough levels were 17\u00a0IU\/dL (5\u201327) at switch and 19\u00a0IU\/dL (10\u201327) at steady state. Significant interindividual variability was observed. Half\u2010life correlated positively with VWF:Ag levels (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.63;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) and body weight (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.62;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In children, mean half\u2010life was 53 h (48\u201359), mean recovery 2.05\u00a0IU\/dL per IU\/kg (1.86\u20132.26), and trough levels 13\u201314\u00a0IU\/dL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PK profiles matched or exceeded those reported in the XTEND studies, with a slightly longer half\u2010life and higher trough FVIII levels. Notable interindividual variability highlights the value of PK assessments, even for ultra\u2010extended half\u2010life FVIII, to optimize individualized patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70306","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:26:23Z","timestamp":1778142383000},"page":"954-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Standard Half\u2010Life: Real\u2010world Pharmacokinetics of Efanesoctocog Alfa in a Single Centre"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-6246","authenticated-orcid":false,"given":"Laurent","family":"Sattler","sequence":"first","affiliation":[{"name":"Laboratoire D'h\u00e9matologie, Unit\u00e9 H\u00e9mostase H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Herb","sequence":"additional","affiliation":[{"name":"Laboratoire D'h\u00e9matologie, Unit\u00e9 H\u00e9mostase H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Pierre","sequence":"additional","affiliation":[{"name":"Centre de Ressource et Comp\u00e9tences des Maladies H\u00e9morragiques Rares H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Laboratoire D'h\u00e9matologie, Unit\u00e9 H\u00e9mostase H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Dolt","sequence":"additional","affiliation":[{"name":"Laboratoire D'h\u00e9matologie, Unit\u00e9 H\u00e9mostase H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Feugeas","sequence":"additional","affiliation":[{"name":"Centre de Ressource et Comp\u00e9tences des Maladies H\u00e9morragiques Rares H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Desprez","sequence":"additional","affiliation":[{"name":"Centre de Ressource et Comp\u00e9tences des Maladies H\u00e9morragiques Rares H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04319-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00278-x"},{"issue":"5","key":"e_1_2_11_4_1","first-page":"1334","article-title":"Emicizumab: The Hemophilia A Game\u2010Changer","volume":"109","author":"Mannucci P. 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