{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:47:54Z","timestamp":1784342874893,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilic arthropathy causes chronic pain and disability. While orthopaedic surgery aims to alleviate these, post\u2010surgical activities of daily living (ADL) and quality of life (QOL) outcomes lack systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess ADL and QOL outcomes after orthopaedic surgery for haemophilic arthropathy and identify research gaps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This scoping review searched MEDLINE, Embase, CENTRAL, CINAHL, and PEDro for studies reporting ADL or QOL outcomes in patients undergoing lower\u2010limb orthopaedic surgery for haemophilic arthropathy. Data were qualitatively synthesised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen studies were included, predominantly on total knee arthroplasty (\n                      <jats:italic>n<\/jats:italic>\n                      = 11). The SF\u201036 was widely used, whereas haemophilia\u2010specific tools were rare. Despite heterogeneous designs, varied follow\u2010ups, and inconsistent mental health results, most studies demonstrated significant post\u2010surgical improvements in physical function and QOL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While standardised, disease\u2010specific assessments are needed, this review confirms surgery consistently improves ADL and QOL. However, it should be noted that it is well known that, in a disease as rare as haemophilia, it is very difficult to conduct Level I evidence studies on orthopaedic surgery (prospective, double\u2010blind, randomized trials). In fact, this study confirms what was already well known empirically: that orthopaedic surgery is effective in relieving or eliminating joint pain thereby improving the QOL for patients with advanced haemophilic arthropathy who have not responded to non\u2010surgical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70311","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:07:14Z","timestamp":1778738834000},"page":"1049-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Activities of Daily Living and Quality of Life After Orthopaedic Surgery for Haemophilic Arthropathy: A Scoping Review"],"prefix":"10.1111","volume":"32","author":[{"given":"Makoto","family":"Asaeda","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Hiroshima University Hospital  Hiroshima Japan"},{"name":"Division of Rehabilitation Department of Clinical Practice and Support Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Taito","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation Department of Clinical Practice and Support Hiroshima University Hospital  Hiroshima Japan"},{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG)  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation Department of Clinical Practice and Support Hiroshima University Hospital  Hiroshima Japan"},{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG)  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation Department of Clinical Practice and Support Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Sato","sequence":"additional","affiliation":[{"name":"Bio\u2010environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Bio\u2010environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Fujita","sequence":"additional","affiliation":[{"name":"Bio\u2010environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Fujitani","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.38022\/ajhp.v4i2.85"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.10.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200407000-00004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00540.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07386.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.08.023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04246.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/jrm.v56.40775"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15444"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2019.1602035"},{"issue":"10","key":"e_1_2_11_13_1","article-title":"Total Knee Replacement as Treatment for Hemophilic Arthropathy: A Case Series","volume":"16","author":"Govindasamy M.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"M.Asaeda S.Taito andY.Nakashima \u201cActivity of daily living and quality of life after orthopedic surgery for hemophilic arthropathy: a protocol for a scoping review \u201d (2025) https:\/\/doi.org\/10.17605\/OSF.IO\/AUZHP.","DOI":"10.1111\/hae.70311"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_11_16_1","volume-title":"The Joanna Briggs Institute Reviewers' Manual 2015","author":"Peters M.","year":"2015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2024.08.013"},{"key":"e_1_2_11_18_1","first-page":"88","volume-title":"Measuring health and disability?: manual for WHO Disability Assessment Schedule (WHODAS 2.0)","author":"Ustun T. B.","year":"2010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13367"},{"key":"e_1_2_11_20_1","first-page":"1294188","volume-title":"The Hemophilia Quality of Life Scale: A Systematic Review","author":"Wang X.","year":"2024"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2024.1786"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14633"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2001.00119.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050140"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13200"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12832"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13224"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1014844"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12875"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0036933013507870"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-016-4340-6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13386"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2706-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12063"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.07.020"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103247"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312116671725"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13777"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-55"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.12.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12885"},{"issue":"1","key":"e_1_2_11_44_1","first-page":"85","article-title":"Long\u2010Term Results of Primary Total Knee Replacement in Patients With Hemophilia","volume":"87","author":"Silva M.","year":"2005","journal-title":"Journal of Bone and Joint Surgery American Volume"},{"issue":"2","key":"e_1_2_11_45_1","first-page":"186","article-title":"Total Knee Replacement in Haemophilic Arthropathy","volume":"89","author":"Rodriguez\u2010Merchan E. C.","year":"2007","journal-title":"Journal of Bone and Joint Surgery British Volume"},{"issue":"12","key":"e_1_2_11_46_1","first-page":"E503","article-title":"Total Knee Arthroplasty in Hemophilic Arthropathy","volume":"44","author":"Rodr\u00edguez\u2010Merch\u00e1n E. C.","year":"2015","journal-title":"American Journal of Orthopedics"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.30795\/jfootankle.2022.v16.1604"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14025"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010199607000\u201000010"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000443"},{"issue":"3","key":"e_1_2_11_51_1","first-page":"645","article-title":"Use of Patient\u2010Reported Outcome Measures in Lower Extremity Research","volume":"18","author":"Zhang Y.","year":"2023","journal-title":"International Journal of Sports Physical Therapy"},{"issue":"4","key":"e_1_2_11_52_1","first-page":"AS131","article-title":"Comparison of a Generic and a Disease\u2010Specific Measure of Pain and Physical Function After Knee Replacement Surgery","volume":"33","author":"Bombardier C.","year":"1995","journal-title":"Medical Care"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:45:35Z","timestamp":1784299535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hae.70311"],"URL":"https:\/\/doi.org\/10.1111\/hae.70311","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2025-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}