{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:14:00Z","timestamp":1789812840270,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Efanesoctocog alfa is a novel recombinant factor VIII (FVIII) with an ultra\u2010extended half\u2010life and stable pharmacokinetics, approved for prophylaxis in children with haemophilia A (HA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the experience of transitioning paediatric patients with HA to efanesoctocog alfa using a comprehensive assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study in a paediatric haemophilia unit. Patients &lt;18 years without inhibitors were transitioned from prior prophylaxis to efanesoctocog alfa. Treatment regimen, adherence, annual bleeding rate (ABR), pharmacokinetics, joint health, sports, quality\u2010of\u2010life, treatment burden, treatment satisfaction\/preference were compared at baseline and during follow\u2010up between efanesoctocog alfa and previous treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen patients (mean age 9.42 years) were included. After 365 \u00b1 84.08 days, adherence improved and no inhibitors were detected. A significant increase in half\u2010life was observed (from 13.57 \u00b1 3.6 to 57.13 \u00b1 6.1 h) which led to a lower ABR score in the series (0.39\u20130.05) and an improvement of joint health after 6 months (\n                      <jats:italic>n<\/jats:italic>\n                      = 15 patients), due to a relevant synovitis reduction (20% reduction in elbows; 13.3% in ankles) despite patients were moderately\u2010highly physically active. Quality\u2010of\u2010life perception improved after 3 months (EQ\u2010VAS increased: 90.72 \u00b1 10.31 to 95.25 \u00b1 5.3;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) as well as treatment burden (HEMO\u2010TEM global score in 12\u201318 year\u2010old patients: 16.08 \u00b1 11.43 to 11.72 \u00b1 14.8). Patients\/caregivers expressed a strong preference for efanesoctocog alfa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transitioning to efanesoctocog alfa was safe and effective in this paediatric cohort. Despite limited follow\u2010up, data suggest this therapy offers meaningful clinical and psychosocial benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70328","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:48:08Z","timestamp":1780134488000},"page":"1170-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Assessment of the Transition to Efanesoctocog Alfa Prophylaxis in a Paediatric Haemophilia A Cohort"],"prefix":"10.1111","volume":"32","author":[{"given":"Rub\u00e9n","family":"Berrueco","sequence":"first","affiliation":[{"name":"Pediatric Hematology Department Hospital Sant Joan De D\u00e9u  Esplugues de Llobregat Spain"},{"name":"Institut De Recerca Sant Joan De D\u00e9u de Barcelona (IRSJD)  Esplugues de Llobregat Spain"},{"name":"Unidad Integrada Hemofilia SJD\u2010HSP (sede pedi\u00e1trica  Esplugues de Llobregat 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