{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:14:16Z","timestamp":1789812856866,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilia is a rare inherited bleeding disorder, and in low\u2010 and middle\u2010income countries, care is often limited by delayed diagnosis and restricted access to specialised services. In Cambodia, care is centralised in only two treatment centres, which may further limit timely diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess perceived barriers to healthcare access among paediatric patients with haemophilia in Cambodia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional survey was conducted in Cambodia from July to December 2025 among 100 reachable patients aged \u226418 years with Haemophilia A or B from a National Hemophilia Registry of 250 patients. Data were collected through telephone or face\u2010to\u2010face interviews using a structured questionnaire administered primarily to parents or caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 100 participants, 88% reported at least one diagnostic barrier, mainly limited caregiver knowledge, difficulty accessing experienced providers, and delayed referral. Barriers to daily home\u2010based bleeding management were reported by 83%, largely related to inadequate caregiver education and limited healthcare support. Barriers to accessing haemophilia treatment centres affected 73%, mainly geographic distance, financial constraints and transportation difficulties. Delays in receiving treatment were reported by 69% and were significantly associated with clotting factor shortages, financial constraints and delayed referral. Clotting factor shortage was not significantly associated with home\u2010based management barriers but contributed to treatment delays. Most participants reported satisfaction with care (82%) and perceived care as equitable (85%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paediatric haemophilia care in Cambodia is limited by geographic, financial, educational and health\u2010system barriers. Improving education, referral pathways, home\u2010care support, clotting factor supply and financial protection may strengthen care access.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70343","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:56:24Z","timestamp":1781513784000},"page":"1200-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perceived Barriers to Healthcare Access Among Paediatric Patients With Haemophilia in Cambodia: A Cross\u2010Sectional Survey"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6954-0492","authenticated-orcid":false,"given":"Chean","family":"Soph\u00e2l","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Immunology Hemophilia Treatment Center, National Pediatric Hospital  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Sivmeng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology Hemophilia Treatment Center, National Pediatric Hospital  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lean","family":"Kimsreng","sequence":"additional","affiliation":[{"name":"Technical Office, National Pediatric Hospital  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ith","family":"Ponndara","sequence":"additional","affiliation":[{"name":"Academic and Training Office University of Health Sciences  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101326786"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2020\u2010004143"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/cjhr.cjhr_44_18"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","unstructured":"Z. Y.Zhou B.Riske A. D.Forsberg et\u00a0al. \u201cSelf\u2010Reported Barriers to Hemophilia Care in People With Factor VIII Deficiency \u201dAmerican Journal of Preventive Medicine41 no. 6 suppl. 4 (2011):S346\u2013S353 https:\/\/dx.doi.org\/10.1016\/j.amepre.2011.09.003.","DOI":"10.1016\/j.amepre.2011.09.003"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349\u20103291.ijcp20233233"},{"key":"e_1_2_14_7_1","unstructured":"World Federation of Hemophilia.World Bleeding Disorders Registry 2020 Data Report[Internet] (WFH 2021) cited November 1 2025 https:\/\/www.wfh.org\/publications\/files\/pdf\u20102046.pdf."},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012486"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2023.23129"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.32641\/andespediatr.v92i2.1090"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S490588"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14998"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14445"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019GS121537"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010024\u201020165\u2010w"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15123"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","unstructured":"B.Jacobs P.Ir M.Bigdeli P.Leslie Annear andW.Van Damme \u201cAddressing Access Barriers to Health Services: An Analytical Framework for Selecting Appropriate Interventions in Low\u2010Income Asian Countries \u201dHealth Policy and Planning27 no.4(July 2012):288\u2013300 https:\/\/doi.org\/10.1093\/heapol\/czr038.","DOI":"10.1093\/heapol\/czr038"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15028"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14176"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:41:47Z","timestamp":1789810907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/hae.70343"],"URL":"https:\/\/doi.org\/10.1111\/hae.70343","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}