{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:19:19Z","timestamp":1787800759063,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Over the past decade, hemophilia management has been transformed by modern prophylactic strategies, achieving dramatic reductions in annualized bleeding rates (ABR), often approaching zero. However, the conceptual evolution of hemophilia care toward multidimensional health assessment and comprehensive multidisciplinary management was initiated more than two decades ago through the adoption of functional, patient\u2010reported, and biopsychosocial outcome frameworks. Despite these advances, their implementation in routine clinical practice remains incomplete, highlighting a persistent disconnect between hemostatic control and overall health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine how recent therapeutic innovations should be integrated within established multidimensional models of hemophilia care and to identify the remaining barriers to their implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative literature review combined with the joint perspective of a French patient representative and hematologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We discuss the need to operationalize multidimensional outcome assessment by integrating patient\u2010reported outcomes, joint health, functional status, participation, and sex\u2010specific bleeding phenotypes, including menstrual bleeding and limitations of ABR as a measure of treatment success. Therapeutic innovation also introduces new challenges requiring individualized care, behavioral adaptation, long\u2010term safety surveillance, and shared decision\u2010making. Persistent implementation gaps include fragmented care pathways, unequal access to multidisciplinary expertise and specialized laboratory support, and limited integration of psychological, functional, cardiovascular, and behavioral dimensions into routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The challenge for modern hemophilia care is no longer to redefine comprehensive, patient\u2010centered management, but to translate long\u2010established multidimensional frameworks into everyday clinical practice. Achieving sustained health, autonomy, and meaningful participation will require strengthening multidisciplinary care models, and ensuring equitable implementation of comprehensive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70376","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:55:14Z","timestamp":1787799314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Bleeding Control to Health: Implementing Multidimensional and Multidisciplinary Hemophilia Care Into the Era of Therapeutic Innovation"],"prefix":"10.1111","author":[{"given":"Nicolas","family":"Giraud","sequence":"first","affiliation":[{"name":"Patient Representative French Hemophilia Association (AFH)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-1463","authenticated-orcid":false,"given":"Yesim","family":"Dargaud","sequence":"additional","affiliation":[{"name":"French Reference Centre For Hemophilia Louis Pradel Hospital  CHU de Lyon France"},{"name":"UR4609 Hemostasis &amp; Thrombosis Research Unit University Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2315","article-title":"Phase 3 Study of Recombinant Factor VIII Fc Fusion Protein in Severe Hemophilia A","volume":"370","author":"Mahlangu J.","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305074"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703068"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803550"},{"issue":"5","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"e322","DOI":"10.1016\/S2352-3026(23)00037-6","article-title":"Fitusiran Prophylaxis in People With Severe Hemophilia A or B Without Inhibitors: A Multicentre, Open\u2010label, Randomised Phase 3 Trial","volume":"10","author":"Srivastava A.","year":"2023","journal-title":"The Lancet Haematology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216455"},{"issue":"12","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"e891","DOI":"10.1016\/S2352-3026(24)00307-7","article-title":"Concizumab Prophylaxis in People With Hemophilia A or B Without Inhibitors (explorer8): Phase 3 Trial","volume":"11","author":"Chowdary P.","year":"2024","journal-title":"The Lancet Haematology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024027468"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2025.101353","article-title":"Long\u2010Term Durability of rAAV Gene Therapy in Hemophilia: Factor Expression, Clinical Outcomes and Underlying Molecular Mechanisms","volume":"75","author":"Dargaud Y.","year":"2025","journal-title":"Blood Reviews"},{"key":"e_1_2_9_11_1","volume-title":"International Classification of Functioning, Disability and Health (ICF)","author":"World Health Organization","year":"2001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01142.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01186.x"},{"issue":"1","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/hae.13088","article-title":"Participants of the International Symposium on Outcome Measures in Hemophilic Arthropathy. 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