{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:19Z","timestamp":1791618559536,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The functional independence score in haemophilia (FISH) is a widely used performance\u2010based assessment tool designed to evaluate musculoskeletal function in children with haemophilia (CWH). Nevertheless, FISH exhibits a ceiling effect in children who are undergoing early prophylaxis or those who present with minimal musculoskeletal impairment. This report describes the development of an enhanced FISH (e\u2010FISH) with more challenging tasks to detect early physical function changes in CWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two performance\u2010based assessments, the basketball throw test (BBT) and the 10\u00d75\u2010meter sprint test (ST) were included as a subtest of FISH. Age\u2010specific normative scores were established from healthy boys. A scoring system, which ranges from 1\u20134, was created and compared with CWH, who showed no joint deformities after obtaining the necessary consent and assent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty CWH with FISH scores ranging from 31\u201332 and on prophylactic treatment with clotting factor concentrate were evaluated using these two tests. Only one (5%) CWH attained a higher score of 4 in both assessments. In the BBT, two (10%) achieved a score of 3, six (30%) received a score of 2, and 11 (55%) were assigned an e\u2010FISH score of 1. In the 10\u00d75 meter ST, eight (40%) scored 3, one (5%) scored 2, and 10 (50%) scored 1 in e\u2010FISH. No bleeding was reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We have created e\u2010FISH as a clinimetric instrument designed for the assessment of individuals with CWH who may exhibit minimal musculoskeletal alterations and demonstrate a ceiling effect when using FISH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70413","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:23:12Z","timestamp":1791616992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Functional Independence Score for Haemophilia (E\u2010FISH) for Early Detection of Musculoskeletal Changes"],"prefix":"10.1111","author":[{"given":"Sanjeev Manasseh","family":"Padankatti","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4693-4422","authenticated-orcid":false,"given":"S","family":"Priyadarshini","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Thomvic","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"},{"name":"Qatar Rehabilitation Institute Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-774X","authenticated-orcid":false,"given":"Paul","family":"Jebaraj","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"},{"name":"RUHSA Department Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Elizabeth","family":"Muppidi","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"},{"name":"Therapy Outpatient Services Mary Bridge Children's Hospital  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Jebaraj","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy Christian Medical College  Vellore Tamil Nadu India"},{"name":"Owen Sound Foundation Brightshores Health System  Owen Sound Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha M","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunny","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-5246","authenticated-orcid":false,"given":"Judy Ann","family":"David","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-9982","authenticated-orcid":false,"given":"Pradeep Mathew","family":"Poonnoose","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aby","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-5020","authenticated-orcid":false,"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"},{"name":"St. John's Medical College Hospital and St. John's Research Institute  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2005.01142.x"},{"key":"e_1_2_14_3_1","unstructured":"Functional Independence Score in Hemophilia (FISH). ELearning Platf 2025 https:\/\/elearning.wfh.org\/resource\/functional\u2010independence\u2010score\u2010in\u2010hemophilia\u2010fish\/(accessedAugust 6 2025)."},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_215_23"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027863"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000376"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000429"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13880"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2011.02496.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2012.02836.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13367"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231224357"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2006.01265.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22291"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1091367X.2021.2021205"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1123\/jtpe.2024\u20100207"},{"key":"e_1_2_14_17_1","first-page":"9","article-title":"Reliability of Sprint Acceleration Performance and Three Repetition Maximum Back Squat Strength in Hurling Players","volume":"2","author":"Byrne P. 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