{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:14Z","timestamp":1791618554290,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemophilic arthropathy (HA) is a progressive, inflammatory joint disease that develops despite effective control of bleeding in people with hemophilia (PWH). Increasing evidence suggests that HA is initiated and then maintained by a complex cycle of synovial macrophage activation, angiogenesis, and cartilage catabolism\u2014pathways shared with osteoarthritis (OA) and inflammatory arthritis. Glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists (GLP\u20101RA), initially developed for diabetes and obesity, have emerged as pleiotropic immunometabolic modulators with potent anti\u2010inflammatory, chondroprotective, anti\u2010angiogenic, and analgesic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review was undertaken to examine the potential role of GLP\u20101RA in HA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although GLP\u20101RA have not yet been studied directly in hemophilia, a large and growing preclinical and clinical literature in OA and inflammatory arthritis provides strong mechanistic justification for their relevance in HA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review integrates experimental, translational, and epidemiologic data on GLP\u20101 signaling in joint biology and proposes a stage\u2010specific framework for how GLP\u20101 pathways might modify HA downstream of bleeding, the initiating event.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70424","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:15:02Z","timestamp":1791616502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implications of Glucagon\u2010Like Peptide\u20101 Signaling for Hemophilic Arthropathy, Joint Inflammation, and Cartilage Degeneration: A Narrative Review"],"prefix":"10.1111","author":[{"given":"Leonard A.","family":"Valentino","sequence":"first","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Dargaud","sequence":"additional","affiliation":[{"name":"French Reference Centre For Hemophilia Louis Pradel Hospital and University of Lyon 1  Lyon France"},{"name":"UR4609 Hemostase et Thrombose Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2025.101304","article-title":"Unmet Needs in Hemophilic Arthropathy","volume":"74","author":"Dargaud Y.","year":"2025","journal-title":"Blood Reviews"},{"issue":"8","key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/17474086.2024.2378936","article-title":"Joint Health and Pain in the Changing Hemophilia Treatment Landscape","volume":"17","author":"Mancuso M. 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