{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:38:48Z","timestamp":1790422728160,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular calcification is highly prevalent in end\u2010stage renal disease and independently predictive of future cardiovascular events and mortality. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>alcification can occur in both the intimal and medial layers of vasculature, but medial calcification is the major form in end\u2010stage renal disease. Medial calcification increases large elastic artery stiffness and pulse\u2010pressure, promotes left ventricular hypertrophy, reduces perfusion of the coronary arteries, and ultimately promotes increased cardiovascular mortality via increased risk of myocardial infarction and heart failure. It results not from a passive deposition of calcium and phosphate due to increased circulating levels, but rather is an active cell\u2010mediated process involving vascular smooth muscle cell apoptosis and vesicle release, a shift in the balance of inhibitors and promoters of vascular calcification, and vascular smooth muscle cell differentiation from a contractile to osteochondrogenic phenotype. This phenotypic shift requires phosphate, as well as the uptake of phosphate by the sodium\u2010dependent phosphate cotransporter <jats:styled-content style=\"fixed-case\">PiT<\/jats:styled-content>\u20101, which is upregulated by proinflammatory cytokines and the uremic milieu. Further research is needed to determine if targeting these processes can ultimately reduce vascular calcification in this high cardiovascular risk population.<\/jats:p>","DOI":"10.1111\/hdi.12084","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T15:13:09Z","timestamp":1382022789000},"source":"Crossref","is-referenced-by-count":76,"title":["Vascular calcification in end\u2010stage renal disease"],"prefix":"10.1111","volume":"17","author":[{"given":"Kristen L.","family":"Jablonski","sequence":"first","affiliation":[{"name":"Division of Renal Diseases and Hypertension University of Colorado Denver Anschutz Medical Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chonchol","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension University of Colorado Denver Anschutz Medical Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"239","article-title":"Cardiovascular disease and mortality in ESRD","volume":"11","author":"Foley RN","year":"1998","journal-title":"J Nephrol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.644"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002028"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422003"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.096358"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg414"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.7.1014"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133194.94939.42"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090631"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00300.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.987"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045557"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00823.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000141775.67189.98"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.07.020"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121191"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070692"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9799"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783738"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12710-9"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.83"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234914"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:31:38Z","timestamp":1694467898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":23,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/hdi.12084"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12084","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}