{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:30:58Z","timestamp":1760549458541},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accelerated vascular calcification is a well\u2010described complication of chronic kidney disease often affecting large and small vessels alike through a variety of mechanisms. Accordingly, dysregulation of calcium and phosphate balance, vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> metabolism, hyperparathyroidism, and endothelial injury can lead to both macrovascular and microvascular complications. We describe a 56\u2010year\u2010old Hispanic male with a history of end\u2010stage renal disease, diabetes mellitus type 2, and medical noncompliance who developed sequential digital ischemia and necrosis involving both hands as well as right foot as a result of M\u00f6nckeberg sclerosis. An extensive metabolic and serologic workup was unrevealing but radiographic studies and histopathology revealed the diagnosis. A multifaceted approach was instituted including wound debridement and amputations along with intensive medical support. In addition to improving hypertensive control and striving for improved calcium and phosphate balance, sodium thiosulfate solution was administered for more than 1 year. This aggressive approach allowed his wounds to heal and has arrested further digital ischemia from occurring.<\/jats:p>","DOI":"10.1111\/hdi.12115","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T11:24:56Z","timestamp":1385378696000},"page":"531-535","source":"Crossref","is-referenced-by-count":1,"title":["Role of sodium thiosulfate therapy in the treatment of digital necrosis due to <scp>M<\/scp>\u00f6nckeberg sclerosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Michael","family":"Brucculeri","sequence":"first","affiliation":[{"name":"Morton Plant Hospital University of South Florida College of Medicine  Clearwater Florida USA"},{"name":"Renal Hypertension Center  Hudson Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Rullan","sequence":"additional","affiliation":[{"name":"Morton Plant Hospital University of South Florida College of Medicine  Clearwater Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonela","family":"Zanchi","sequence":"additional","affiliation":[{"name":"Morton Plant Hospital University of South Florida College of Medicine  Clearwater Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Marcotte","sequence":"additional","affiliation":[{"name":"Morton Plant Hospital University of South Florida College of Medicine  Clearwater Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.160"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027616"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02120508"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.00082.x"},{"key":"e_1_2_4_6_1","first-page":"43","article-title":"Monckeberg sclerosis revisited","volume":"132","author":"Micheletti RG","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_7_1","first-page":"498","volume-title":"Pathologic Basis of the Disease","author":"Cotran RS","year":"1999"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0896-5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2010.079"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2008.07.009"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00183.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00170.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200207000-00011"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.194"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq089"},{"key":"e_1_2_4_16_1","first-page":"63","article-title":"Successful sodium thiosulfate treatment for recurrent calcium urolithiasis","volume":"23","author":"Yatzidis H","year":"1985","journal-title":"Clin Nephrol"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599409180482"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229009060727"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000188861"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:18:01Z","timestamp":1696339081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/hdi.12115"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12115","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,25]]}}}