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During <jats:styled-content style=\"fixed-case\">UF<\/jats:styled-content>, several liters of fluid are removed; however, what proportion of this fluid is removed from which fluid space could not be clinically measured easily until now; we designed this study to evaluate the fluid spaces most affected by <jats:styled-content style=\"fixed-case\">UF<\/jats:styled-content>. This is a prospective cohort study of 40 prevalent chronic hemodialysis patients receiving thrice weekly hemodiafiltration (<jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content>). We measured the patients' fluid spaces using a whole\u2010body bioimpedance apparatus to evaluate the changes of fluid spaces before and immediately after the <jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content> sessions. We recorded the data on fluid spaces, <jats:styled-content style=\"fixed-case\">UF<\/jats:styled-content> volume, and blood pressures. The cohort consisted of 40 prevalent <jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content> patients, aged 60.0\u2009\u00b1\u20095.2 years (37.5% men; 27.5% people with diabetes), and body weight 71.03\u2009\u00b1\u200915.48\u2009kg. Achieved <jats:styled-content style=\"fixed-case\">UF<\/jats:styled-content> was 2.38\u2009\u00b1\u20090.98\u2009L on <jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content> (measured fluid overload: 2.35\u2009\u00b1\u20091.44\u2009L). The extracellular fluid (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>) volume decreased from 16.84\u2009\u00b1\u20093.52 to 14.89\u2009\u00b1\u20093.06\u2009L (P\u2009&lt;\u20090.0001) and intracellular fluid (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) volume from 16.88\u2009\u00b1\u20094.40 to 16.55\u2009\u00b1\u20094.48\u2009L (P\u2009=\u20090.45). Although urea volume of distribution remained effectively unchanged (31.38\u2009\u00b1\u20097.28 vs. 30.70\u2009\u00b1\u20097.32\u2009L; P\u2009=\u20090.45), the degree of <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> volume overload decreased from 13.60%\u2009\u00b1\u20097.30% to 3.83%\u2009\u00b1\u20098.32% (P\u2009&lt;\u20090.0001). The mean arterial pressure also decreased from 122.95\u2009\u00b1\u200919.02 to 108.50\u2009\u00b1\u200913.91\u2009mmHg (P\u2009&lt;\u20090.0001). We conclude that source of net fluid loss by ultrafiltration is almost exclusively the <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> fluid space. The intracellular fluid space is not significantly affected immediately after <jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hdi.12125","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T02:06:51Z","timestamp":1390183611000},"page":"384-390","source":"Crossref","is-referenced-by-count":25,"title":["Which fluid space is affected by ultrafiltration during hemodiafiltration?"],"prefix":"10.1111","volume":"18","author":[{"given":"Mih\u00e1ly B.","family":"Tapolyai","sequence":"first","affiliation":[{"name":"Fresenius Medical Care Semmelweis University  Budapest Hungary"},{"name":"Department of Medicine, Division of Nephrology WJB Dorn VA Medical Center  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Faludi","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Semmelweis University  Budapest 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