{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:34:54Z","timestamp":1780536894718,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are the beta\u2010lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin\/tazobactam use. This report presents a case of a hypertensive and diabetic 67\u2010year\u2010old woman in regular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia, which was initially treated with cefepime. Two days after treatment, she presented dysarthria, left hemiparesis, ataxia, and <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> cranial nerves paresis. Computed tomography showed no acute lesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced by piperacillin\/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin\/tazobactam treatment, the neurological manifestations returned. A new computed tomography showed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysis sessions, the patient completely recovered from neurological manifestations. The patient presented sequentially neurotoxicity caused by two beta\u2010lactams antibiotics. This report meant to alert clinicians that these antibiotics have dangerous neurological effects in chronic kidney disease patients.<\/jats:p>","DOI":"10.1111\/hdi.12194","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T11:23:04Z","timestamp":1407410584000},"page":"143-145","source":"Crossref","is-referenced-by-count":8,"title":["Piperacillin\/tazobactam\u2010induced neurotoxicity in a hemodialysis patient: A case report"],"prefix":"10.1111","volume":"19","author":[{"given":"Precil Diego M. M.","family":"Neves","sequence":"first","affiliation":[{"name":"Internal Medicine Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda M.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane A.","family":"Kojima","sequence":"additional","affiliation":[{"name":"Nephrology Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz L.","family":"Carmello","sequence":"additional","affiliation":[{"name":"Nephrology Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bazan","sequence":"additional","affiliation":[{"name":"Neurology Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasqual","family":"Barretti","sequence":"additional","affiliation":[{"name":"Nephrology Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Nephrology Department University of S\u00e3o Paulo State  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"92","article-title":"Solu\u00e7o intrat\u00e1vel desencadeado por ingest\u00e3o de carambola (averrhoa carambola) em portadores de insufici\u00eancia renal cr\u00f4nica","volume":"15","author":"Martin LC","year":"1993","journal-title":"J Bras Nefrol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1373\/clinchem.2007.096412","article-title":"Drug monitoring and toxicology","volume":"54","author":"Graaf P","year":"2008","journal-title":"Clin Chem"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G526"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2012.36.1.159"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1170-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn256"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm713"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31803195e7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh048"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:08:16Z","timestamp":1695560896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/hdi.12194"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12194","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}