{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:42:39Z","timestamp":1791924159334,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperkalemia in hemodialysis patients is associated with high mortality, but prescription of low dialysate potassium concentrations to decrease serum potassium levels is associated with a high incidence of sudden cardiac arrest or sudden death. Improved clinical outcomes for these patients may be possible if rapid and substantial intradialysis decreases in serum potassium concentration can be avoided while maintaining adequate potassium removal. Data from kinetic modeling sessions during the <jats:styled-content style=\"fixed-case\">HEMO<\/jats:styled-content> Study of the dependence of serum potassium concentration on time during hemodialysis treatments and 30 minutes postdialysis were evaluated using a pseudo one\u2010compartment model. Kinetic estimates of potassium mobilization clearance (<jats:styled-content style=\"fixed-case\">K<jats:sub>M<\/jats:sub><\/jats:styled-content>) and predialysis central distribution volume (<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content><jats:sub>pre<\/jats:sub>) were determined in 551 hemodialysis patients. The studied patients were 58.8\u2009\u00b1\u200914.4 years of age with predialysis body weight of 72.1\u2009\u00b1\u200915.1\u2009kg; 306 (55.4%) of the patients were female and 337 (61.2%) were black. <jats:styled-content style=\"fixed-case\">K<jats:sub>M<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content><jats:sub>pre<\/jats:sub> for all patients were non\u2010normally distributed with values of 158 (111, 235) (median [interquartile range]) mL\/min and 15.6 (11.4, 22.8) L, respectively. <jats:styled-content style=\"fixed-case\">K<jats:sub>M<\/jats:sub><\/jats:styled-content> was independent of dialysate potassium concentration (P\u2009&gt;\u20090.2), but <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content><jats:sub>pre<\/jats:sub> was lower at higher dialysate potassium concentration (R\u2009=\u2009\u22120.188, P\u2009&lt;\u20090.001). For patients with dialysate potassium concentration between 1.6 and 2.5\u2009mEq\/L (N\u2009=\u2009437), multiple linear regression of <jats:styled-content style=\"fixed-case\">K<jats:sub>M<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content><jats:sub>pre<\/jats:sub> demonstrated positive association with predialysis body weight and negative association with predialysis serum potassium concentration. Potassium kinetics during hemodialysis can be described using a pseudo one\u2010compartment model.<\/jats:p>","DOI":"10.1111\/hdi.12195","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T04:49:08Z","timestamp":1407214148000},"page":"23-32","source":"Crossref","is-referenced-by-count":30,"title":["Potassium kinetics during hemodialysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Baris U.","family":"Agar","sequence":"first","affiliation":[{"name":"Medical Products (Renal) Baxter Healthcare Corporation  Deerfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce F.","family":"Culleton","sequence":"additional","affiliation":[{"name":"Medical Products (Renal) Baxter Healthcare Corporation  Deerfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Fluck","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Leypoldt","sequence":"additional","affiliation":[{"name":"Medical Products (Renal) Baxter Healthcare Corporation  Deerfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70364-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90465-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04451206"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00806.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.315"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08850811"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000182015"},{"key":"e_1_2_6_9_1","first-page":"366","article-title":"Potassium removal as a factor limiting the correction of acidosis during dialysis","volume":"19","author":"Redaelli B","year":"1983","journal-title":"Proc Eur Dial Transplant Assoc"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(89)80132-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.8.1629"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1681\/ASN.V11122337","article-title":"Effect of dialysate sodium concentration on interdialytic increase of potassium","volume":"11","author":"De Nicola L","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP59130"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1492-7535.2005.01144.x"},{"key":"e_1_2_6_15_1","first-page":"145","article-title":"A comprehesive model of the dynamic exchange processes during hemodialysis","volume":"16","author":"Thews O","year":"1990","journal-title":"Med Prog Technol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/6.3.180"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014406"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.245"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880602901103"},{"key":"e_1_2_6_20_1","first-page":"384","article-title":"Simple model of intra\u2010extracellular potassium kinetics and removal applied to constant and potassium\u2010profiled dialysis","volume":"21","author":"Bolasco P","year":"2008","journal-title":"J Nephrol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00806.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03860411"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2012.00706.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.205"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(00)00062-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021583"},{"key":"e_1_2_6_27_1","first-page":"1672","volume-title":"The Kidney","author":"Gotch FA","year":"1976"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2003.16102.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.274"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080402400102"},{"key":"e_1_2_6_31_1","first-page":"302","article-title":"Dynamic behavior of plasma phosphate in chronic dialysis patients","volume":"28","author":"Sugisaki H","year":"1982","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198109000-00002"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880002301104"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a092135"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000094485.54491.68"},{"key":"e_1_2_6_36_1","volume-title":"Basic Principles of Membrane Transport","author":"Schultz SG","year":"1980"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167176"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.039"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh661"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12069"},{"key":"e_1_2_6_41_1","unstructured":"LeypoldtJK AgarBU BernardoA CulletonBF.Prescriptions of dialysate potassium concentrations during short daily and long nocturnal (high dose) haemodialysis. Abstract presented at 2014 ERA\u2010EDTA Meeting 2014."}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12195","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:08:03Z","timestamp":1695560883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/hdi.12195"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12195","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}