{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:40:49Z","timestamp":1790685649247,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Wenzhou Technology Program","award":["2011s0221"],"award-info":[{"award-number":["2011s0221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>The purpose of this study was to investigate the correlation of conjunctival and corneal calcification (CCC<\/jats:styled-content>) with cardiovascular calcification in patients undergoing maintenance hemodialysis (MHD<\/jats:styled-content>). A total of 122 patients undergoing MHD<\/jats:styled-content> in our hospital were included in this study. Conjunctival and corneal calcification was examined by slit lamp and graded. Abdominal aortic calcification (AAC<\/jats:styled-content>), aortic valve calcification (AVC<\/jats:styled-content>), and mitral valve calcification (MVC<\/jats:styled-content>) were determined by X<\/jats:styled-content>\u2010ray or ultrasound. The correlation of CCC<\/jats:styled-content> with AAC<\/jats:styled-content>, AVC<\/jats:styled-content>, and MVC<\/jats:styled-content> was analyzed. Biochemical, hematological, and cardiovascular data were compared between patients with different severity of CCC<\/jats:styled-content> or AAC<\/jats:styled-content>. Mitral valve calcification was significantly associated with AAC<\/jats:styled-content> in our patients. Conjunctival and corneal calcification positively correlated with AAC<\/jats:styled-content>. We also found that patients with severe CCC<\/jats:styled-content> exhibited significantly higher levels of serum calcium, phosphate, product of calcium and phosphate, serum copper, cystatin, intact parathyroid hormone, and vitamin D<\/jats:styled-content> than patients with mild CCC<\/jats:styled-content>. In addition to significantly increased levels of serum calcium, product of calcium and phosphate, serum copper, and cystatin, patients with severe AAC<\/jats:styled-content> also had higher high\u2010sensitivity C<\/jats:styled-content>\u2010reactive protein level and greater left ventricular posterior wall thickness and left ventricular end\u2010diastolic interventricular septum thickness than patients with mild AAC<\/jats:styled-content>. Our results suggest that patients undergoing MHD<\/jats:styled-content> with severe CCC<\/jats:styled-content> or AAC<\/jats:styled-content> have high degree of mineral metabolism disorder, inflammation, and cardiovascular function disorder. The strong correlation between CCC<\/jats:styled-content> and AAC<\/jats:styled-content> indicates that CCC<\/jats:styled-content> score might be used as an indirect indicator to predict cardiovascular risks in patients undergoing MHD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hdi.12236","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T03:35:26Z","timestamp":1415331326000},"page":"270-278","source":"Crossref","is-referenced-by-count":12,"title":["Correlation between conjunctival and corneal calcification and cardiovascular calcification in patients undergoing maintenance hemodialysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Wenxue","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of 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