{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:11:20Z","timestamp":1788869480423,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Project of Technology Committee in Shanghai","award":["12DJ1400200"],"award-info":[{"award-number":["12DJ1400200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n The aim of this study is to investigate the effects of endogenous vasoactive substances on the occurrence of intradialytic hypertension (\n IDH<\/jats:styled-content>\n ) in patients during maintenance hemodialysis. Thirty\u2010four maintenance hemodialysis patients were enrolled in this trial, and 17 of them were diagnosed with\n IDH<\/jats:styled-content>\n (defined as an increase in blood pressure of at least 10\u2009mmHg during or immediately after a hemodialysis session), while 17 age\u2010matched and sex\u2010matched controls without\n IDH<\/jats:styled-content>\n were selected for a retrospective comparison. We collected patients' blood samples before and after a dialysis session and measured the plasma levels of\n N<\/jats:styled-content>\n \u2010terminal fragment brain natriuretic peptide, renin, angiotensin\u2010II, aldosterone (\n ALD<\/jats:styled-content>\n ), angiotensin\u2010converting enzyme (\n ACE<\/jats:styled-content>\n ), endothelin\u20101 (\n ET<\/jats:styled-content>\n \u20101), nitric oxide (\n NO<\/jats:styled-content>\n ), norepinephrine (\n NOR<\/jats:styled-content>\n ), and adrenomedullin. The post\u2010dialysis serum\n ET<\/jats:styled-content>\n \u20101 concentrations were significantly higher (4.09\u2009\u00b1\u20092.06 vs. 2.75\u2009\u00b1\u20091.34\u2009pg\/mL, P\u2009<\u20090.05), while the post\u2010dialysis ratio of\n NO<\/jats:styled-content>\n to\n ET<\/jats:styled-content>\n \u20101 was lower (17.79\u2009\u00b1\u20095.65 vs. 24.78\u2009\u00b1\u200912.04, P\u2009<\u20090.05) in\n IDH<\/jats:styled-content>\n patients compared with the control group. Post\u2010dialysis\n ALD<\/jats:styled-content>\n and\n NOR<\/jats:styled-content>\n values were significantly lower (P\u2009<\u20090.01) and\n ACE<\/jats:styled-content>\n levels were significantly higher (P\u2009<\u20090.01) than the pre\u2010dialysis concentrations only in the control and not in the\n IDH<\/jats:styled-content>\n group. All other measured factors did not differ significantly between the groups and between pre\u2010dialysis and post\u2010dialysis determinations. Compared with blood angiotensin\u2010II,\n ALD<\/jats:styled-content>\n ,\n ACE<\/jats:styled-content>\n ,\n NOR<\/jats:styled-content>\n , adrenomedullin,\n N<\/jats:styled-content>\n \u2010terminal fragment brain natriuretic peptide, and\n NO<\/jats:styled-content>\n status, inappropriately elevated\n ET<\/jats:styled-content>\n \u20101 plasma concentrations may play a predominant role in the pathogenesis of\n IDH<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/hdi.12238","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T03:04:37Z","timestamp":1414119877000},"page":"279-286","source":"Crossref","is-referenced-by-count":17,"title":["Inappropriately elevated endothelin\u20101 plays a role in the pathogenesis of intradialytic hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Jie","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital Shanghai Medical College Fudan University No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Dialysis Institute of Shanghai No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Blood Purification Laboratory of Shanghai No 180 Fenglin Road Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital Shanghai Medical College Fudan University No 180 Fenglin Road Shanghai 200032 China"},{"name":"Department of Blood Purification Fujian Provincial Hospital No 134 Dong Street Fuzhou 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Lv","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital Shanghai Medical College Fudan University No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Dialysis Institute of Shanghai No 180 Fenglin Road Shanghai 200032 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital Shanghai Medical College Fudan University No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Dialysis Institute of Shanghai No 180 Fenglin Road Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital Shanghai Medical College Fudan University No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Dialysis Institute of Shanghai No 180 Fenglin Road Shanghai 200032 China"},{"name":"Kidney and Blood Purification Laboratory of Shanghai No 180 Fenglin Road Shanghai 200032 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