{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T22:02:49Z","timestamp":1750370569520},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Severe hyperparathyroidism is a challenge on hemodialysis. The definition of dialysate calcium (Ca<\/jats:styled-content>) is a pending issue with renewed importance in cases of individualized dialysis schedules and of portable home dialysis machines with low\u2010flow dialysate. Direct measurement of calcium mass transfer is complex and is imprecisely reflected by differences in start\u2010to\u2010end of dialysis Ca<\/jats:styled-content> levels. The study was performed in a dialysis unit dedicated to home hemodialysis and to critical patients with wide use of daily and tailored schedules. The Ca<\/jats:styled-content>\u2010phosphate (P<\/jats:styled-content>)\u2010parathyroid hormone (PTH<\/jats:styled-content>) profile includes creatinine, urea, total and ionized Ca<\/jats:styled-content>, albumin, sodium, potassium, P<\/jats:styled-content>, PTH<\/jats:styled-content> levels at start, mid, and end of dialysis. \u201cSevere\u201d secondary hyperparathyroidism was defined as PTH<\/jats:styled-content>\u2009>\u2009300\u2009pg\/mL<\/jats:styled-content> for \u22653 months. Four schedules were tested: conventional dialysis (polysulfone dialyzer 1.8\u20132.1\u2009m2<\/jats:sup>), with dialysate Ca<\/jats:styled-content> 1.5 or 1.75\u2009mmol\/L<\/jats:styled-content>, NxStage<\/jats:styled-content> (Ca<\/jats:styled-content> 1.5\u2009mmol\/L<\/jats:styled-content>), and NxStage<\/jats:styled-content> plus intradialytic Ca<\/jats:styled-content> infusion. Dosages of vitamin D<\/jats:styled-content>, calcium, phosphate binders, and Ca<\/jats:styled-content> mimetic agents were adjusted monthly. Eighty Ca<\/jats:styled-content>\u2010P<\/jats:styled-content>\u2010PTH<\/jats:styled-content> profiles were collected in 12 patients. Serum phosphate was efficiently reduced by all techniques. No differences in start\u2010to\u2010end PTH<\/jats:styled-content> and Ca<\/jats:styled-content> levels on dialysis were observed in patients with PTH<\/jats:styled-content> levels\u2009<\u2009300\u2009pg\/mL<\/jats:styled-content>. Conversely, Ca<\/jats:styled-content> levels in \u201csevere\u201d secondary hyperparathyroid patients significantly increased and PTH<\/jats:styled-content> decreased during dialysis on all schedules except on N<\/jats:styled-content>xstage (P<\/jats:styled-content>\u2009<\u20090.05). Our data support the need for tailored dialysate Ca<\/jats:styled-content> content, even on \u201clow\u2010flow\u201d daily home dialysis, in \u201csevere\u201d secondary hyperparathyroid patients in order to increase the therapeutic potentials of the new dialysis techniques.<\/jats:p>","DOI":"10.1111\/hdi.12296","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:09:35Z","timestamp":1427494175000},"page":"572-582","source":"Crossref","is-referenced-by-count":3,"title":["Calcium\u2010phosphate and parathyroid intradialytic profiles: A potential aid for tailoring the dialysate calcium content of patients on different hemodialysis schedules"],"prefix":"10.1111","volume":"19","author":[{"given":"Martina","family":"Ferraresi","sequence":"first","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pia","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Guzzo","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica Neve","family":"Vigotti","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mongilardi","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Nazha","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Aroasio","sequence":"additional","affiliation":[{"name":"Laboratory Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Gonella","sequence":"additional","affiliation":[{"name":"Laboratory Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Avagnina","sequence":"additional","affiliation":[{"name":"Dietetics and Clinical Nutrition Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgina Barbara","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Nephrology Unit Department of Clinical and Biological Sciences San Luigi Gonzaga Hospital University of Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12941213"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"e_1_2_7_5_1","first-page":"391","article-title":"Vitamin D status and mortality of German hemodialysis patients","volume":"32","author":"Krause R","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1747"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0684-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6330"},{"key":"e_1_2_7_9_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"113","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD\u2010MBD Work Group","year":"2009","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_7_10_1","volume-title":"Hyperphosphataemia in Chronic Kidney Disease: Management of Hyperphosphataemia in Patients with Stage 4 or 5 Chronic Kidney Disease","author":"Centre for Clinical Practice at NICE (UK)","year":"2013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs418"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001593"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011070688"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft514"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000209249"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/540592"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs119"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2006.00125.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.08.033"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00172.x"},{"issue":"7","key":"e_1_2_7_21_1","first-page":"vii37","article-title":"The choice of the dialysate calcium concentration in the management of patients on haemodialysis and haemodiafiltration","volume":"18","author":"Malberti F","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp365"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr733"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10000912"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mat.0000227687.88929.08"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245924"},{"key":"e_1_2_7_27_1","first-page":"579","article-title":"Dialysate calcium individualisation: A pending issue","volume":"32","author":"Maduell F","year":"2012","journal-title":"Nefrologia"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2008.00244.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09580911"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04650512"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.357"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337050"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00424.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00399.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp170"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027616"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12252"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.01.004"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12168"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2010.00475.x"},{"key":"e_1_2_7_41_1","first-page":"76","article-title":"Home hemodialysis \u00e0 la carte: A tailormade program (1998\u20132003)","volume":"17","author":"Piccoli GB","year":"2004","journal-title":"J Nephrol"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1681\/ASN.V12102131","article-title":"Association of elevated serum PO(4), Ca\u2009\u00d7\u2009PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients","volume":"12","author":"Ganesh SK","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-172"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.019"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.09.067"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/039139880402700312","article-title":"Maintenance of residual renal function 10 years after the start of hemodialysis: The advantage of tailored schedules?","volume":"27","author":"Piccoli GB","year":"2004","journal-title":"Int J Artif Organs"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12320"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-013-0001-8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05130610"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp597"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.157"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2009.00053.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187861"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2004.00001.x"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:34:09Z","timestamp":1695569649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,26]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/hdi.12296"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12296","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,26]]}}}