{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:51:40Z","timestamp":1779101500204,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Carnitine deficiency is known to occur in chronic hemodialysis; however, the effect of continuous renal replacement therapy (CRRT<\/jats:styled-content>) on carnitine homeostasis has not been studied. We hypothesized that children receiving CRRT<\/jats:styled-content> are at risk for deficiency because of continuous removal, absent intake, decreased production, and comorbidities related to critical illness. Records of patients with acute kidney injury receiving CRRT<\/jats:styled-content> at C<\/jats:styled-content>hildren's N<\/jats:styled-content>ational H<\/jats:styled-content>ealth S<\/jats:styled-content>ystem between 2011 and 2014 were reviewed for total carnitine (TC<\/jats:styled-content>), free carnitine (FC<\/jats:styled-content>), feeding modality, severity of illness, and survival outcome. The proportion of carnitine\u2010deficient patients at baseline, 1, 2, and \u22653 weeks on CRRT<\/jats:styled-content> were compared by chi\u2010square, and relationships with other variables assessed by P<\/jats:styled-content>earson's correlation and logistic regression. The study group included 42 CRRT<\/jats:styled-content> patients, age 7.9\u2009+\u20091.1 years. At baseline, 30.7% and 35.7% of patients were TC<\/jats:styled-content> and FC<\/jats:styled-content> deficient. Within 1 week, 64.5% (P\u2009=\u20090.03) and 70% (P\u2009=\u20090.03) were TC<\/jats:styled-content> and FC<\/jats:styled-content> deficient, and prevalence of deficiency increased to 80% (P\u2009=\u20090.01) and 90% (P\u2009=\u20090.008) by 2 weeks; 100% of patients were TC<\/jats:styled-content> and FC<\/jats:styled-content> deficient after being on CRRT<\/jats:styled-content> for \u22653 weeks (P\u2009=\u20090.005 and P\u2009=\u20090.01, respectively, vs. baseline). TC<\/jats:styled-content> and FC<\/jats:styled-content> levels negatively correlated with days on CRRT<\/jats:styled-content> (r\u2009=\u2009\u22120.39, P\u2009=\u20090.001 and r\u2009=\u2009\u22120.35, P\u2009=\u20090.005). Patients with TC<\/jats:styled-content> and FC<\/jats:styled-content> deficiency had 5.9 and 4.9 greater odds of death than those with normal levels (P\u2009=\u20090.02 and P\u2009=\u20090.03). Carnitine is significantly and rapidly depleted with longer time on CRRT<\/jats:styled-content>, and carnitine deficiency is associated with increased mortality. Consequences of deficiency and benefits of supplementation in the pediatric CRRT<\/jats:styled-content> population should be investigated.<\/jats:p>","DOI":"10.1111\/hdi.12341","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:50:56Z","timestamp":1439340656000},"page":"63-67","source":"Crossref","is-referenced-by-count":31,"title":["Carnitine deficiency in children receiving continuous renal replacement therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"Kristen","family":"Sgambat","sequence":"first","affiliation":[{"name":"Department of Nephrology Children's National Health System Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Moudgil","sequence":"additional","affiliation":[{"name":"Department of Nephrology Children's National Health System Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2014.10.025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90093-Y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1177\/039139880002300205","article-title":"Correlation between plasma carnitine, muscle carnitine and glycogen levels in maintenance hemodialysis patients","volume":"23","author":"Debska S","year":"2000","journal-title":"Int J Artif Organs"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-68"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a2bbd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496410"},{"key":"e_1_2_6_9_1","first-page":"890","article-title":"[Related factor of serum carnitine deficiency and influence of its deficiency on the length of hospital stay in critical ill patients]","volume":"26","author":"Zhou Z","year":"2014","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3JS4C"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00041"},{"key":"e_1_2_6_12_1","unstructured":"The ASPEN (American Society for Parenteral and Enteral Nutrition).Pediatric Nutrition Support Core Curriculum.270\u2013271 2010."},{"key":"e_1_2_6_13_1","volume-title":"A Pilot Study Aimed to Evaluate the Loss of Carnitine During IHF and CVVH in Acute Kidney Injury Patients","author":"Pacitti A","year":"2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013584"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000421598"},{"key":"e_1_2_6_16_1","first-page":"209","article-title":"Body composition and long\u2010term levo\u2010carnitine supplementation","volume":"149","author":"Trovato GM","year":"1998","journal-title":"Clin Ter"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000606"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2144-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32833e10d4"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:50:37Z","timestamp":1696301437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,11]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/hdi.12341"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12341","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,11]]}}}