{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:31:44Z","timestamp":1790706704153,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) is linked to chronic kidney disease. However, few studies have examined the prevalence, risk factors, or outcomes of <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> in patients with chronic hemodialysis and concomitant heart failure. This retrospective cohort study enrolled 160 patients with a history of acute decompensated heart failure after maintenance hemodialysis therapy. All patients were prospectively observed until <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2013 or death. <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> was defined as pulmonary artery systolic pressure\u2009&gt;35\u2009mmHg, as determined through echocardiography. Fifty\u2010one (32%) patients had <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>, more of whom were female (70% vs. 52%, P\u2009=\u20090.04). The patients with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> had a lower body mass index (21.8 vs. 23.0, P\u2009=\u20090.03), higher cardiothoracic ratio (55% vs. 52%, P\u2009=\u20090.006), larger left atrium (38.5 vs. 35.7\u2009mm, P\u2009=\u20090.01), and an increased proportion of mitral regurgitation (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) (73% vs. 38%, P\u2009&lt;\u20090.001) compared with the patients who did not have <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. In the multivariate regression analysis, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> was associated most strongly with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> (odds ratio 3.75, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.67\u20138.43, P\u2009=\u20090.001). In the multivariate Cox proportional hazard models, <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> was related independently to all\u2010cause mortality (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>], 3.11; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.53\u20136.31; P\u2009=\u20090.002) and combined cardiovascular events (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 2.71; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.66\u20134.44; P\u2009&lt;\u20090.001) after the model was adjusted for conventional cardiovascular risk factors. <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> is related to <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> and independently associated with increased all\u2010cause mortality and cardiovascular events in patients with chronic hemodialysis and heart failure.<\/jats:p>","DOI":"10.1111\/hdi.12380","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T08:24:39Z","timestamp":1447403079000},"page":"208-217","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary hypertension in patients on chronic hemodialysis and with heart failure"],"prefix":"10.1111","volume":"20","author":[{"given":"Chin\u2010wen","family":"Hsieh","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Pingtung Christian Hospital  Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010te","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Chang\u2010Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"Department of Medicine Chang Gung University College of Medicine  Taoyuan 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