{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:17:04Z","timestamp":1778152624459,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction<\/jats:bold> High sodium intake is the main cause of fluid overload in hemodialysis (HD) patients, leading to increased cardiovascular mortality. High sodium intake is known to be associated with low salt taste acuity and\/or high preference. As the zinc status could influence taste acuity, we analyzed the effect of zinc deficiency on salt taste acuity, preference, and dietary sodium intake in HD patients. <jats:bold>Methods<\/jats:bold> A total of 77 HD patients was enrolled in this cross\u2010sectional study. Zinc deficiency was defined as serum zinc level with below 70 \u00b5g\/mL. The patients were divided into two groups based on serum zinc level. Salt taste acuity and preference were determined by a sensory test using varying concentrations of NaCl solution, and dietary sodium intake was estimated using 3\u2010day dietary recall surveys. <jats:bold>Findings<\/jats:bold> The mean salt recognition threshold and salt taste preference were significantly higher in the zinc deficient group than in the non\u2010zinc deficient group. And there was significant positive correlation between salt taste preference and dietary sodium intake in zinc deficient group (<jats:italic>r<\/jats:italic>\u2009=\u20090.43, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Although, the dietary sodium intake showed a high tendency with no significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.052), interdialytic weight gain was significantly higher in the zinc deficient group than in the non\u2010zinc deficient group (2.68\u2009\u00b1\u20091.02 kg vs. 3.18\u2009\u00b1\u20091.02 kg; <jats:italic>P<\/jats:italic>\u2009=\u20090.047). <jats:bold>Discussion<\/jats:bold> Zinc deficiency may be related to low salt taste acuity and high salt preference, leading to high dietary sodium intake in HD patients.<\/jats:p>","DOI":"10.1111\/hdi.12388","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T07:06:43Z","timestamp":1454396803000},"page":"441-446","source":"Crossref","is-referenced-by-count":10,"title":["The effect of zinc deficiency on salt taste acuity, preference, and dietary sodium intake in hemodialysis patients"],"prefix":"10.1111","volume":"20","author":[{"given":"So Mi","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Jeju National University Hospital, Jeju National University School of Medicine Jeju Republic of Korea"},{"name":"Department of Dietetics and Nutrition Service Jeju National Hospital Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Jeju National University Hospital, Jeju National University School of Medicine Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun kyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Dankook University Hospital, Dankook University College of Medicine Cheonan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center, University of Ulsan, College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Won","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center, University of Ulsan, College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Jeju National University Hospital, Jeju National University School of Medicine Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001374"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040430"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/ajcn\/22.9.1240","article-title":"Metabolic role of zinc","volume":"22","author":"Mills CF","year":"1969","journal-title":"Am J Clin Nutr."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2007.00756.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400105"},{"key":"e_1_2_6_7_1","first-page":"125","article-title":"Serum zinc concentrations in the maintenance hemodialysis patients","volume":"30","author":"Dvornik S","year":"2006","journal-title":"Coll 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