{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:51:56Z","timestamp":1770137516032,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:bold>Introduction<\/jats:bold> Blood volume changes and vascular refilling during hemodialysis (HD) and ultrafiltration (UF) have been assumed to depend on volume overload (<jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub>). It was the aim to study the magnitude of vascular refilling in stable HD patients with moderate volume expansion in everyday dialysis using novel technical approaches. <jats:bold>Methods<\/jats:bold> Patients were studied during routine dialysis and UF based on clinical dry weight assessment. Pre\u2010dialysis <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> was independently measured by bioimpedance spectroscopy. Vascular refilling volume (<jats:italic>V<\/jats:italic><jats:sub>ref<\/jats:sub>) was calculated as: <jats:italic>V<\/jats:italic><jats:sub>ref<\/jats:sub>\u2009=\u2009<jats:italic>V<\/jats:italic><jats:sub>uf<\/jats:sub>\u2009\u2212\u2009<jats:italic>\u0394V<\/jats:italic>, where <jats:italic>\u0394V<\/jats:italic> is the absolute blood volume change determined by on\u2010line dialysate dilution using a commercial on\u2010line hemodiafiltration machine incorporating a relative blood volume monitor, and where <jats:italic>V<\/jats:italic><jats:sub>uf<\/jats:sub> is the prescribed UF volume. <jats:bold>Findings<\/jats:bold> Thirty patients (dry weight: 81.0\u2009\u00b1\u200917.8 kg) were studied. Pre\u2010dialysis <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> was 2.46\u2009\u00b1\u20091.45 L. <jats:italic>V<\/jats:italic><jats:sub>uf<\/jats:sub> was 2.27\u2009\u00b1\u20090.71 L, specific UF rate was 6.45\u2009\u00b1\u20092.43 mL\/kg\/h, and since \u0394V was 0.66\u2009\u00b1\u20090.31 L, <jats:italic>V<\/jats:italic><jats:sub>ref<\/jats:sub> was determined as 1.61\u2009\u00b1\u20090.58 L, corresponding to a constant refilling fraction (<jats:italic>F<\/jats:italic><jats:sub>ref<\/jats:sub>) of 70.6\u2009\u00b1\u200910.6%. <jats:italic>V<\/jats:italic><jats:sub>ref<\/jats:sub> strongly correlated with <jats:italic>V<\/jats:italic><jats:sub>uf<\/jats:sub> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.82) but was independent of <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> and other volumes. <jats:italic>F<\/jats:italic><jats:sub>ref<\/jats:sub> was also independent of <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> and other volumes normalized for various measures of body size. <jats:bold>Discussion<\/jats:bold> While vascular refilling and <jats:italic>F<\/jats:italic><jats:sub>ref<\/jats:sub> is independent of <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> in treatments with moderate UF requirements, intravascular volume depletion increases with increasing UF requirements. The relationship between blood volume and <jats:italic>V<\/jats:italic><jats:sub>o<\/jats:sub> needs to be more closely examined in further studies to optimize volume control in everyday dialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12417","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:02:10Z","timestamp":1460307730000},"page":"484-491","source":"Crossref","is-referenced-by-count":27,"title":["Vascular refilling is independent of volume overload in hemodialysis with moderate ultrafiltration requirements"],"prefix":"10.1111","volume":"20","author":[{"given":"Susanne","family":"Kron","sequence":"first","affiliation":[{"name":"Department of Nephrology Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schneditz","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical University of Graz Graz 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