{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:08:09Z","timestamp":1767892089163,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["94\/109"],"award-info":[{"award-number":["94\/109"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction:<\/jats:bold> Pruritus is one of the frustrating skin manifestations of advanced renal failure. Many options have been used for the management of uremic pruritus (UP) such as pregabalin. There are some studies that reported beneficial effects of pregabalin in reducing UP; however, most of them did not have a comparator arm. Therefore, we designed this study to compare antipruritic effects of pregabalin with doxepin in the management of pruritus in hemodialysis patients. <jats:bold>Methods:<\/jats:bold> Seventy\u2010two patients suffering from UP were randomly assigned to receive pregabalin (50 mg every other day) or doxepin (10 mg per day) for 4 weeks. Severity of pruritus and its effect on quality of life were assessed by visual analog scale (VAS), 5\u2010D itch scale and dermatology life quality index (DLQI) at baseline and after 1 week, 2 weeks and 4 weeks of the treatment. <jats:bold>Findings:<\/jats:bold> Mean scores of the VAS decreased from 7.5\u00b1 1.4 and 7.1\u2009\u00b1\u20091.3 at baseline to 2.1\u2009\u00b1\u20092.6 and 4.2\u2009\u00b1\u20092.6 at the end of the study (P\u2009&lt;\u20090.001) in the pregabalin and doxepin groups, respectively. Similarly, pregabalin significantly reduced mean scores of the 5\u2010D itch scale and the DLQI compared to doxepin. The most reported side effect in each group was somnolence which occurred in similar rates in the both groups. <jats:bold>Discussion:<\/jats:bold> Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients.<\/jats:p>","DOI":"10.1111\/hdi.12455","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T05:10:37Z","timestamp":1468213837000},"page":"63-71","source":"Crossref","is-referenced-by-count":53,"title":["Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Nazanin","family":"Foroutan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Etminan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shafa Hospital, Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naemeh","family":"Nikvarz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, and Department of Nephrology Shafa Hospital, Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohadese","family":"Shojai Shahrokh Abadi","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Faculty of Medical Sciences Tarbiat Modares University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00346.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.454"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110651"},{"key":"e_1_2_6_5_1","first-page":"241","article-title":"The impact of pruritus on the quality of life of patients undergoing dialysis: a single centre cohort study","volume":"22","author":"Tessari G","year":"2009","journal-title":"J Nephrol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1075"},{"key":"e_1_2_6_7_1","first-page":"161","article-title":"Uremic pruritus in chronic hemodialysis patients","volume":"21","author":"Narita I","year":"2008","journal-title":"J Nephrol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1492-7535.2005.01130.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi204"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2010.00190.x"},{"key":"e_1_2_6_11_1","first-page":"86","article-title":"Gabapentin in the treatment of uremic itch: An index case and a pilot evaluation","volume":"18","author":"Manenti L","year":"2005","journal-title":"J Nephrol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.03.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002757"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01655.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287643.13410.5e"},{"key":"e_1_2_6_16_1","first-page":"669","article-title":"Tricyclic antidepressants and histamine H1 receptors","volume":"54","author":"Richelson E.","year":"1979","journal-title":"Mayo Clinic Proceed"},{"key":"e_1_2_6_17_1","first-page":"34","article-title":"Low\u2010dose doxepin for treatment of pruritus in patients on hemodialysis","volume":"1","author":"Pour\u2010Reza\u2010Gholi F","year":"2007","journal-title":"Iran J Kidney Dis"},{"issue":"213","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00015555-0369","article-title":"Pruritus: A review","volume":"83","author":"Weisshaar E","year":"2003","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"e_1_2_6_19_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","author":"National Kidney Foundation.","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"e_1_2_6_20_1","first-page":"S1","article-title":"KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease","volume":"45","author":"National Kidney Foundation.","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.13.25"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0060"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09586.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.9.1558"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl461"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-5-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000251"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2012.09.016"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0795-x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.128"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000349943"},{"key":"e_1_2_6_32_1","first-page":"132","article-title":"Eliminating bias in randomized controlled trials: Importance of allocation concealment and masking","volume":"39","author":"Viera AJ","year":"2007","journal-title":"Fam Med"},{"key":"e_1_2_6_33_1","first-page":"345","article-title":"Practical tips for surgical research: Blinding: Who, what, when, why, how?","volume":"53","author":"Karanicolas PJ.","year":"2010","journal-title":"Can J Surg"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12455","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:24:35Z","timestamp":1695515075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/hdi.12455"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12455","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}