{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:12:06Z","timestamp":1696320726992},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T00:00:00Z","timestamp":1479600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immobility\u2010induced hypercalcaemia is rarely considered in patients on dialysis and is a challenging diagnosis to make. This is especially so due to the lack of biomarkers as well as the notion that calcium metabolism is mostly related to chronic kidney disease\u2010metabolic bone disorder due to the role of iPTH. We present two cases of our dialysis patients, who were clinically unwell from hypercalcemia. We were initially uncertain of the cause of hypercalcemia as despite our attempts to adjust treatment based on their biochemical findings, we were unable to correct the hypercalcemia. We did not have appropriate bone turnover markers to guide us and out of desperation, anti\u2010resorptives\u2014calcitonin and bisphosphonate were given with good clinical response. We concluded that the hypercalcemia was related to immobility\u2010induced hypercalcemia and the inappropriately low iPTH was a red herring. Immobility\u2010induced hypercalcaemia should be considered in patients with end stage renal failure on renal replacement therapy, especially in those with recent and significant immobility. In these patients, pamidronate can be considered should the hypercalcaemia persist.<\/jats:p>","DOI":"10.1111\/hdi.12512","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:52:41Z","timestamp":1479689561000},"source":"Crossref","is-referenced-by-count":2,"title":["Unusual cause of hypercalcaemia in end stage renal failure patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Hooi Khee","family":"Teo","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital Outram Road Singapore 169 608 Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital Outram Road Singapore 169 608 Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-1-9-711"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002769"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2001.00340.x"},{"key":"e_1_2_4_5_1","first-page":"S3","article-title":"KIDGO clinical practice guideline for the diagnosis, evaluation, preventation, and treatment of chronic kidney disease\u2014Mineral and bone disorder (CKD\u2010MBD) kidney disease: Improving Global Outcomes","volume":"76","author":"KDIGO","year":"2009","journal-title":"Kidney International."},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200009000-00010"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.19093"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70272-1"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000210142.76331.b4"},{"key":"e_1_2_4_10_1","first-page":"46","article-title":"Immobilization induced hypercalcaemia","volume":"13","author":"Cano\u2010Torres EA","year":"2016","journal-title":"Clin Cases Miner Bone Metab."},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.628313"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5981.468"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2014.09.006"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051524"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.762.244"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.781.918"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1613"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs116"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1502"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.03.005"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1154"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:27:44Z","timestamp":1696260464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,20]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/hdi.12512"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12512","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,20]]}}}