{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:34:45Z","timestamp":1787963685197,"version":"build-2784847793"},"reference-count":77,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Among end\u2010stage renal disease patients maintained by hemodialysis, anemia has been managed primarily through erythropoiesis\u2010stimulating agents (ESAs) and intravenous (IV) iron. Following concerns about the cardiovascular (CV) safety of ESAs and changes in the reimbursement policies in Medicare's ESRD program, the use of IV iron has increased. IV iron supplementation promotes hemoglobin production and reduces ESA requirements, yet there exists relatively little evidence on the long\u2010term safety of iron supplementation in hemodialysis patients. Labile iron can induce oxidative stress and is also essential in bacterial growth, leading to concerns about IV iron use and risk of CV events and infections in hemodialysis patients. Existing randomized controlled trials provide little evidence about safety due to insufficient power and short follow\u2010up; recent observational studies have been inconsistent, but some have associated iron exposure with increased risk of infections and CV events. Given the widespread use and potential safety concerns related to IV iron, well\u2010designed large prospective studies are needed to assess to identify optimal strategies for iron administration that maximize its benefits while avoiding potential risks.<\/jats:p>","DOI":"10.1111\/hdi.12558","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T11:09:23Z","timestamp":1491390563000},"source":"Crossref","is-referenced-by-count":17,"title":["Safety of intravenous iron in hemodialysis patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaojuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"},{"name":"UNC Kidney Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit V.","family":"Kshirsagar","sequence":"additional","affiliation":[{"name":"UNC Kidney Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Brookhart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.109"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12112465"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu104"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.10.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050606"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065485"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062276"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907845"},{"key":"e_1_2_7_11_1","first-page":"49029","article-title":"Centers for Medicare & Medicaid Services, HHS. Medicare program; end\u2010stage renal disease prospective payment system. Final rule","volume":"75","year":"2010","journal-title":"Fed Regist."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.03.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-264"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.09.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02600315"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00648.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00174.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00600.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K187"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi253"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200394t"},{"key":"e_1_2_7_22_1","first-page":"279","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes Anemia Work Group","year":"2012","journal-title":"Kidney Int Suppl."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.06.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.08.001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.02.156"},{"key":"e_1_2_7_27_1","unstructured":"Nephrology News & Issues. Implementing an IV iron administration protocol within a dialysis organization. Available from:http:\/\/www.nephrologynews.com(accessed date: March 22 2015)."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03370414"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03300430028018"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.111492"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00314.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00872.x"},{"key":"e_1_2_7_33_1","first-page":"1","article-title":"Tolerability and efficacy of parenteral iron therapy in haemodialysis patients: A comparison of preparations","volume":"1","author":"Moniem KA","year":"2007","journal-title":"Transfus Altern Transfus Med."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701278208"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21794"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv142"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15572"},{"key":"e_1_2_7_38_1","unstructured":"European Medicines Agency. Available from:http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/news_and_events\/news\/2013\/06\/news_detail_001833.jsp&mid=WC0b01ac058004d5c1(accessed date: December 15 2016)."},{"key":"e_1_2_7_39_1","unstructured":"FDA strengthens warnings and changes prescribing instructions to decrease the risk of serious allergic reactions with anemia drug Feraheme (ferumoxytol). US Food and Drug Administration Drug Safety Communications. Available from:http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/UCM440336.pdf(accessed date: May 11 2015)."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01420406"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000124892.90999.cb"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33917"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1296218"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00580.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.109.906230"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.246108"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.46.255"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035250.66458.67"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs488"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00659.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358336"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040423"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050295"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078930"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.275"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000128009.69594.BE"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-11-16"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.11.1827"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094343"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.163"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu201"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1999.v34.aajkd0344b0047"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1092029"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.055Suppl.69035.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12168"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4822"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121164"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.114"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114144"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu349"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP66348"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110032"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12550"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.11.030"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-154"},{"key":"e_1_2_7_78_1","first-page":"1","article-title":"Intravenous iron administration strategies and anemia management in hemodialysis patients","volume":"0","author":"Michels WM","year":"2016","journal-title":"Nephrol Dial Transplant."}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:48:54Z","timestamp":1694627334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":77,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/hdi.12558"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12558","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}