{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:46:37Z","timestamp":1759481197855},"reference-count":41,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anemia is common among patients with chronic kidney disease (CKD) and it is managed primarily with erythropoiesis\u2010stimulating agents (ESA) and iron therapy. Following concerns around ESA therapy and economic constraints, IV iron is more and more administered worldwide.<\/jats:p><jats:p>Several guidelines or position papers, which give indications on iron therapy in CKD patients, have been issued in Nephrology. Unfortunately, the field is characterized by a lack of evidence. As a result, the recommendations\/suggestions are not uniform.<\/jats:p><jats:p>There is general consensus to prescribe iron therapy to patients who are clearly iron deficient. In addition, iron therapy may increase Hb values, delay the start of ESA therapy in ESA\u2010na\u00efve patients and reduce ESA dose in ESA\u2010treated patients. However, there is debate on the safety and efficacy of IV iron therapy when given in the presence of already high serum ferritin levels. In addition, not all the guidelines\/position papers differentiate between non\u2010dialysis\/dialysis patients and between the presence\/absence of ESA therapy. Many international Bodies or Societies suggest caution when administering IV iron during infections. A trial of oral iron should be considered as a first step, especially in the ND\u2010CKD population. Finally, recommendations on the prevention of anaphylactic reactions following IV iron therapy are given by several bodies. There is consensus that IV iron is to be administered in the presence of resuscitative facilities (including medications) and personnel trained for emergencies.<\/jats:p>","DOI":"10.1111\/hdi.12562","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T08:03:15Z","timestamp":1493020995000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical practice guidelines on iron therapy: A critical evaluation"],"prefix":"10.1111","volume":"21","author":[{"given":"Lucia","family":"Del Vecchio","sequence":"first","affiliation":[{"name":"Department of Nephrology and Dialysis Alessandro Manzoni Hospital Lecco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Alessandro Manzoni Hospital Lecco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907845"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1014187"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn238"},{"key":"e_1_2_9_5_1","first-page":"192","article-title":"Dialysis Outcomes Quality Initiative (NKF\u2010DOQI): Clinical practice guidelines for the treatment of anaemia of chronic renal failure","volume":"30","author":"Anaemia Work Group for National Kidney Foundation","year":"1997","journal-title":"Am J Kidney Dis."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.suppl_5.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00894.x"},{"key":"e_1_2_9_8_1","first-page":"279","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","year":"2012","journal-title":"Kidney Int Suppl."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.10.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft033"},{"key":"e_1_2_9_11_1","unstructured":"Available from:http:\/\/www.cari.org.au\/Dialysis\/dialysis%20biochemical%20hematological\/KHA_CARI_Guideline_Fe_in_CKD_16_July_2013.pdf(accessed date: March 7 2017)."},{"key":"e_1_2_9_12_1","volume-title":"Anaemia Management in Chronic Kidney Disease: National Clinical Guideline for Management in Adults and Children","author":"National Collaborating Centre for Chronic Conditions","year":"2006"},{"key":"e_1_2_9_13_1","unstructured":"Available from:https:\/\/www.nice.org.uk\/guidance\/ng8(accessed date: February 21 2017)."},{"key":"e_1_2_9_14_1","first-page":"S287","article-title":"Canadian Society of Nephrology Clinical Practice Guidelines. 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