{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:25:36Z","timestamp":1790702736286,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["C02.2019"],"award-info":[{"award-number":["C02.2019"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["17088.2802"],"award-info":[{"award-number":["17088.2802"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:bold>Introduction<\/jats:bold>: While concentric left ventricular hypertrophy (cLVH) predominates in non\u2013dialysis\u2010dependent chronic kidney disease (CKD), eccentric left ventricular hypertrophy (eLVH) is most prevalent in dialysis\u2010dependent CKD stage 5 (CKD5D). In these patients, the risk of sudden death is 5\u00d7 higher than in individuals with cLVH. Currently, it is unknown which factors determine left ventricular (LV) geometry and how it changes over time in CKD5D.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: Data from participants of the CONvective TRAnsport Study who underwent serial transthoracic echocardiography were used. Based on left ventricular mass (LVM) and relative wall thickness (RWT), 4 types of left ventricular geometry were distinguished: normal, concentric remodeling, eLVH, and cLVH. Determinants of eLVH were assessed with logistic regression. Left ventricular geometry of patients who died and survived were compared. Long\u2010term changes in RWT and LVM were evaluated with a linear mixed model.<\/jats:p><jats:p><jats:bold>Findings<\/jats:bold>: Three hundred twenty\u2010two patients (63.1\u2009\u00b1\u200913.3 years) were included. At baseline, LVH was present in 71% (cLVH: 27%; eLVH: 44%). Prior cardiovascular disease (CVD) was positively associated with eLVH and \u00df\u2010blocker use inversely. None of the putative volume parameters showed any relationship with eLVH. Although eLVH was most prevalent in non\u2010survivors, the distribution of left ventricular geometry did not vary over time.<\/jats:p><jats:p><jats:bold>Discussion<\/jats:bold>: The finding that previous CVD was positively associated with eLVH may result from the permanent high cardiac output and the strong tendency for aortic valve calcification in this group of long\u2010term hemodialysis patients, who suffer generally also from chronic anemia and various other metabolic derangements. No association was found between eLVH and parameters of fluid balance. The distribution of left ventricular geometry did not alter over time. The assumption that LV geometry worsens over time in susceptible individuals, who then suffer from a high risk of dying, may explain these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12644","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T18:18:34Z","timestamp":1519409914000},"page":"359-368","source":"Crossref","is-referenced-by-count":16,"title":["Left ventricular geometric patterns in end\u2010stage kidney disease: Determinants and course over time"],"prefix":"10.1111","volume":"22","author":[{"given":"Menso J.","family":"Nub\u00e9","sequence":"first","affiliation":[{"name":"Department of Nephrology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiny","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Doganer","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel L.","family":"Bots","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Blankestijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus","family":"van den Dorpel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Maasstad Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Kamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet M.","family":"Ter Wee","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camiel L. M.","family":"de Roij van Zuijdewijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amsterdam Cardiovascular Sciences, VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel P. 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