{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:20:55Z","timestamp":1761844855349},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastatic pulmonary calcification (MPC) was seen in 79% of patients with end\u2010stage renal disease (ESRD) during autopsy. However, it is not commonly diagnosed in vivo. Its pathogenesis is not fully understood. We report a retrospective series of 5 cases of MPC from a single center in Singapore. MPC were diagnosed using radiological or histological features. Mean onset of MPC from diagnosis of ESRD was 22.6\u2009\u00b1\u20093.1 years. One patient remains asymptomatic. Four patients died, one was related to MPC. All patients had calcifications at the lung apices on radiological studies. Three patients with MPC were diagnosed based on radiological features while 2 had histological features. Four patients underwent parathyroidectomy without radiological changes before parathyroidectomy. Median intact parathyroid hormone of this series was 5.6 pmol\/L (IQR 1.3\u2013139.4), alkaline phosphatase 74 U\/L (IQR 62\u2013461), calcium 2.10 mmol\/L (IQR 1.85\u20132.40), and phosphate 1.30 mmol\/L (IQR 0.87\u20131.63). The observed low iPTH suggests that MPC might occur in low iPTH. Our case series showed MPC might occur in low iPTH after parathyroidectomy, in contrast to existing literature that suggests MPC is diagnosed in patients with elevated iPTH. Parathyroidectomy does not prevent MPC.<\/jats:p>","DOI":"10.1111\/hdi.12658","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T16:58:25Z","timestamp":1522688305000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic pulmonary calcification: Experience from a single center in Singapore"],"prefix":"10.1111","volume":"22","author":[{"given":"Swee Ping","family":"Teh","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen Li","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Singapore General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau Ang Anthony","family":"Yii","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Changi General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Lin Lina","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Singapore General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"402","article-title":"Soft tissue calcification in chronic dialysis patients","volume":"86","author":"Kuzela DC","year":"1977","journal-title":"Am J Pathol."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr591"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/53649455"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.2840"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu163"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121191"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-3-330"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.01.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.1999.0716"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2108054"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/archinte.1977.03630160080016","article-title":"Metastatic pulmonary calcification in primary hyperparathyroidism","volume":"137","author":"Cohen AM","year":"1977","journal-title":"Arch Intern Med."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.3.384"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry","volume":"0","author":"Brandenburg VM","year":"2016","journal-title":"Nephrol Dial Transplant."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.04.035"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T06:28:15Z","timestamp":1694845695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/hdi.12658"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12658","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,2]]},"assertion":[{"value":"2017-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}