{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:17:03Z","timestamp":1759540623319},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p><jats:bold>Introduction:<\/jats:bold> Polysulfone (PSf) membrane has been widely used for hemodialysis. A few studies have been reported in which a method of sterilization may affect biocompatibility. In this study, the comparison was made between two PSf membranes in order to evaluate the effect of sterilization from the biocompatibility point of view.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We investigated the biocompatibility of the following two dialyzers, that is, APS\u201011SA (Asahi Kasei medical Co., Tokyo, Japan), sterilized by gamma\u2010ray irradiation, and RENAK PS\u20101.0 (Kawasumi laboratories, Tokyo, Japan), sterilized by autoclave. Heparin of 40 units\/mL was put in a syringe, and test blood was collected from healthy volunteers. Then, the dialyzer and blood circuit were filled with the test blood. Subsequently, the blood was circulated by a roller pump at the rate of 200 mL\/min. We measured the platelet counts, CD41 and CD42b platelet surface markers, beta\u2010thromboglobulin (beta\u2010TG) and platelet factor 4 (PF4) at 30, 120, and 240 minutes, respectively.<\/jats:p><jats:p><jats:bold>Findings:<\/jats:bold> The platelet counts at 30, 120, and 240 minutes decreased significantly from the initiation of blood circulation in both dialyzers. The average beta\u2010TG and PF4 increased from 61.3 \u00b1 22.1 and 17.0 \u00b1 6.4 ng\/mL to 680.7 \u00b1 217.1 and 550.7 \u00b1 116.7 ng\/mL with APS\u201011SA and to 454.3 \u00b1 85.6 and 402.0 \u00b1 58.0 ng\/mL with RENAK PS\u20101.0, respectively. The average expression of CD41 and CD42b in APS\u201011SA and RENAK PS\u20101.0 was similar.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> There are some reports that the gamma\u2010ray irradiation changes the membrane structure of the PSf membrane, crosslinking the polyvinylpyrrolidone (PVP), a hydrophilic agent, on to the membrane. On the other hand, excess amount of PVP may have been eluted during the rinsing procedure in RENAK PS\u20101.0 because it was sterilized with autoclave. Because both these factors influenced on our results, APS\u201011SA and RENAK PS\u20101.0 dialyzers showed excellent blood compatibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12698","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T06:30:31Z","timestamp":1541745031000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of biocompatibility in polysulfone dialysis membranes with different sterilization"],"prefix":"10.1111","volume":"22","author":[{"given":"Konomi","family":"Togo","sequence":"first","affiliation":[{"name":"Department of Medical Course, Faculty of Health and Medical Science Teikyo Heisei University  Tokyo Japan"},{"name":"Department of Chemical Science and Technology Faculty of Bioscience and Applied Chemistry, Hosei University  Tokyo Japan"},{"name":"Kodokan Bldg. Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Technology Faculty of Bioscience and Applied Chemistry, Hosei University  Tokyo Japan"},{"name":"Kodokan Bldg. Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Technology Faculty of Bioscience and Applied Chemistry, Hosei University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyuki","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Technology Faculty of Bioscience and Applied Chemistry, Hosei University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Kodokan Bldg. Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Ebine","sequence":"additional","affiliation":[{"name":"Kodokan Bldg. Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro C.","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Technology Faculty of Bioscience and Applied Chemistry, Hosei University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12592"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12223"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12595"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.130"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1499"},{"key":"e_1_2_7_7_1","first-page":"75","article-title":"Will differences in the sterilization of a polysulfone membrane affect antibiotic properties?","volume":"20","author":"Yamashita F","year":"2012","journal-title":"J Jpn Soc Technol Hemopurification"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00181-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.1.172.413k17_172_178"},{"key":"e_1_2_7_10_1","first-page":"514","article-title":"Loss of fibrinogen receptors from the platelet surface during simulated extracorporeal circulation","volume":"105","author":"Musial J","year":"1985","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30365"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.3860"},{"key":"e_1_2_7_13_1","first-page":"377","article-title":"Analysis of Glanzmann's thrombasthenia and Bernard\u2010Soulier syndrome using flow cytometry","volume":"28","author":"Nomura S","year":"1987","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181984229"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4009\/jsdt.45.845"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4009\/jsdt1968.18.207"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:28:08Z","timestamp":1694489288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":15,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/hdi.12698"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12698","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}