{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:11:59Z","timestamp":1768281119542,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:bold>Introduction<\/jats:bold>: Achieving euvolemia is one of the major challenges when treating end\u2010stage renal disease (ESRD) patients receiving maintenance renal replacement therapy. Fluid overload is recognized as an independent predictor of mortality in ESRD, but its association with chronic inflammation is less well explored especially in chronic maintenance hemodiafiltration.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: We performed a cross\u2010sectional study of 87 prevalent ESRD patients receiving chronic maintenance hemodiafiltration (vintage 66.5\u2009\u00b1\u200957.1\u2009months) with bioimpedance analysis to characterize the degree of percent overhydration (OH%). We also compared the levels of inflammatory markers, including C\u2010reactive protein (CRP), serum albumin, neutrophil\/lymphocyte ratio (NLR), and hemoglobin red cell distribution width (RDW) for the overhydrated (OH%\u2009\u2265\u200915%) versus euvolemic (OH%\u2009&lt;\u200915%) groups. Linear regression analysis was performed to explore relationships between the degree of OH and inflammatory indicators.<\/jats:p><jats:p><jats:bold>Findings<\/jats:bold>: The cohort represented an all\u2010European population with a mean age of 60.9\u2009\u00b1\u200914.7\u2009years and prevalence of diabetes mellitus of 27%. The entire cohort's OH% was 14.9%\u2009\u00b1\u20095.1% (range \u221211.1% to 39.0%); further, the &lt;15% group of patients\u2019 OH% was 8.0%\u2009\u00b1\u20098.5% versus 20.9%\u2009\u00b1\u20095.1% in the OH%\u2009\u2265\u200915% group (P\u2009&lt;\u20090.0001). Forty\u2010seven patients (53%) were overhydrated by traditional criteria (OH%\u2009\u226515%) and 20 patients (23%) were severely overhydrated (OH%\u2009&gt;\u200920%). The euvolemic (OH% &lt;15%) versus severely overhydrated (OH% &gt;\u200920%) groups had significant differences in markers of inflammation: CRP (9.8\u2009\u00b1\u200910.6 vs. 21.5\u2009\u00b1\u200921.6\u2009mg\/L, P\u2009&lt;\u20090.006), serum albumin (37.6\u2009\u00b1\u200902.9 vs. 34.5\u2009\u00b1\u20095.3\u2009g\/L, P\u2009&lt;\u20090.004), and NLR (3.06\u2009\u00b1\u20091.25 vs. 3.92\u2009\u00b1\u20092.04; P\u2009&lt;\u20090.004). On linear regression, significant correlations were found between OH% and CRP (r\u2009=\u20090.2899, P\u2009&lt;\u20090.006), serum albumin (r\u2009=\u2009\u22120.3670; P\u2009&lt;\u20090.0005), RDW (r\u2009=\u20090.2992; P\u2009&lt;\u20090.005), and NLR (r\u2009=\u20090.2900; P\u2009&lt;\u20090.006).<\/jats:p><jats:p><jats:bold>Discussion<\/jats:bold>: In a prevalent hemodiafiltration cohort, OH was common and correlated with several inflammatory markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12742","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T09:36:26Z","timestamp":1551778586000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association of overhydration with chronic inflammation in chronic maintenance hemodiafiltration patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Lajos","family":"Zsom","sequence":"first","affiliation":[{"name":"Fresenius Medical Care  Cegl\u00e9d Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"Faludi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-7040","authenticated-orcid":false,"given":"Tibor","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Medical Services Ralph H. 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