{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:57:07Z","timestamp":1791046627613,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009230","name":"Landstinget i Uppsala l\u00e4n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:bold>Introduction:<\/jats:bold> Fluid management in hemodialysis patients is a controversial topic. Brain natriuretic peptide (BNP) is secreted from the heart in response to volume overload, and may be a marker of overhydration in hemodialysis patients. Our aim was to investigate the correlation between BNP and overhydration in a cohort of hemodialysis patients, and to find out whether BNP and overhydration correlate in repeated measurements within individuals with elevated BNP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study was prospective, observational, and had a cross\u2010sectional part and a longitudinal follow\u2010up. The distribution of BNP was investigated in a cohort of 64 hemodialysis patients. Blood samples and bioimpedance spectroscopy measurements were performed before midweek dialysis. Subsequently, 11 study participants with elevated BNP concentrations (&gt;500\u2009pg\/mL) were assessed in another nine dialysis sessions each. These individuals also had their cardiac function and heart rate variability (HRV) examined.<\/jats:p><jats:p><jats:bold>Findings:<\/jats:bold> BNP was above 500\u2009pg\/mL in 38% of the participants, and correlated positively with overhydration (r<jats:sub>s<\/jats:sub> =\u20090.381), inflammation and malnutrition, but not with systolic blood pressure. In comparison to participants with BNP below 500\u2009pg\/mL, participants with elevated BNP were older, had lower muscle strength, lower bodyweight and lower levels of hemoglobin and albumin. Echocardiography revealed cardiac anomalies in all 11 participants in the longitudinal follow\u2010up, and HRV, as measured by SDNN, was pathologically low. In repeated measurements, the between\u2010individuals variation of BNP in relation to overhydration was greater (SD\u2009=\u20090.581) than the within\u2010person variation (SD\u2009=\u20090.285).<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> BNP correlates positively to overhydration, malnutrition, and inflammation. In a subgroup of patients with elevated BNP, who are mainly elderly and frail, BNP reflects individual variation in hydration status, and hence seems to be a modifiable marker of overhydration. These data suggest that BNP is best applied for measuring changes in hydration status within an individual over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12751","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T07:12:36Z","timestamp":1552029156000},"page":"402-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Brain natriuretic peptide reflects individual variation in hydration status in hemodialysis patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-0087","authenticated-orcid":false,"given":"Jenny","family":"Stenberg","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Melin","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala 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