{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:30:38Z","timestamp":1774459838109,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003348","name":"Fukuda Foundation for Medical Technology","doi-asserted-by":"publisher","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}],"id":[{"id":"10.13039\/501100003348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous studies have demonstrated an association between low serum creatinine levels and adverse outcomes in patients undergoing maintenance hemodialysis. However, little is known regarding whether long\u2010term changes in serum creatinine predict outcomes independently and incrementally over a single point evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum creatinine data at index (June 2013) and for the 18\u2009months prior to the index blood sampling (between January 2012 and June 2013) were evaluated in 346 hemodialysis patients. Patients were followed from the index blood sampling for primary (all\u2010cause mortality) and secondary (cardiovascular death) endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>During a median follow\u2010up of 5.7\u2009years, there were 82 all\u2010cause and 25 cardiovascular deaths. Compared to patients who survived, those who died displayed a greater time\u2010dependent reduction in creatinine levels during the 18\u2009months prior to the index assessment, coupled with a greater decrease in predialysis body weight (interaction p = 0.007). Patients who displayed creatinine decline over the prior 18\u2009months (\u2206 creatinine&lt;0\u2009mg\/dL) had higher all\u2010cause mortality than those who maintained creatinine levels (\u2206 creatinine\u22650\u2009mg\/dL). After adjustment for clinical factors and baseline creatinine index, antecedent creatinine decrease was independently associated with an increased risk of all\u2010cause mortality, with an incremental prognostic value over baseline creatinine index alone. A reduction in creatinine levels was also associated with cardiovascular death independent of the baseline creatinine index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A long\u2010term antecedent decrease in serum creatinine levels is independently associated with clinical outcomes in hemodialysis patients, with an incremental prognostic value over baseline creatinine index alone. Our data suggest that serial creatinine measurements are a useful prognosticator in practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12794","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:40:49Z","timestamp":1571668849000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The relationship between antecedent creatinine decreases and outcomes in patients undergoing hemodialysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Tomonari","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Sorimachi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Obokata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Sunaga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Hidaka Hospital  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Ito","sequence":"additional","affiliation":[{"name":"Hidaka Hospital  Takasaki Gunma Japan"},{"name":"Department of Nephrology Heisei\u2010Hidaka Clinic  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Hidaka Hospital  Takasaki Gunma Japan"},{"name":"Department of Medicine Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Ando","sequence":"additional","affiliation":[{"name":"Hidaka Hospital  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kurabayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Negishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine  Maebashi Gunma Japan"},{"name":"Nepean Clinical School, Faculty of Medicine and Health University of Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"USRDS. 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Kidney disease statistics for the United States.2015; Available from:https:\/\/www.niddk.nih.gov\/health\u2010information\/health\u2010statistics\/kidney\u2010disease."},{"key":"e_1_2_7_4_1","unstructured":"The Japanese Society for Dialysis Therapy. 2016 statistics of maintenance Dialysis therapy in Japan.2016; Available from:http:\/\/docs.jsdt.or.jp\/overview\/pdf2017\/p004.pdf."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr389"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0336"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323972"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.05.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093286"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158122"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft213"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006885"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.12.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-018-0385-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-018-1472-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.02.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192278"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1681\/ASN.V471475","article-title":"Lean Body Mass Estimation","volume":"4","author":"Keshaviah R","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0079-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2017.12.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0391398818762355"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02080310"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008974"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000100127.54107.57"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhdi.12794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.12794","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:53:27Z","timestamp":1694166807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/hdi.12794"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12794","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,21]]},"assertion":[{"value":"2019-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}