{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:25:47Z","timestamp":1767651947503},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002769","name":"Bushehr University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Protein energy wasting is an adverse consequence of renal failure, which is correlated with increased mortality and morbidity. Metabolic acidosis has a major role in the development of protein energy wasting in hemodialysis patients. Every effort that could ameliorate this catabolic state would be beneficial to stabilize body composition. The aim of this study was to investigate the possible beneficial effects of high bicarbonate dialysis on anthropometric indices and biochemical parameters of nutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six hemodialysis patients were randomly enrolled in two groups: an intervention group that underwent hemodialysis for 6\u2009months with high bicarbonate dialysate concentration (36\u2009mmol\/L, N = 26) and a control group that underwent hemodialysis using a bicarbonate dialysate concentration of 30\u2009mmol\/L (N = 30). Biochemical parameters of nutrition and weight, body mass index (BMI), total body water, percent body fat, and other anthropometric indices were measured at the beginning and the end of the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>At the end of the 6\u2009month evaluation period, plasma levels of albumin, phosphorus, K, calcium, and bicarbonate showed no significant changes. Body weight and BMI increased significantly in high bicarbonate arm but did not change significantly in the control group. Percent body fat in the arms and legs did not change in intervention arm, but decreased significantly in the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results suggest that higher bicarbonate dialysis can have beneficial effects on nutritional status and might protect against loss of fat mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12842","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T03:24:50Z","timestamp":1589772290000},"page":"317-322","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of high bicarbonate hemodialysis solution on biochemical parameters and anthropometric indices"],"prefix":"10.1111","volume":"24","author":[{"given":"Farnaz","family":"Hefzollah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Bushehr University of Medical Sciences  Bushehr 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