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We describe the case of a 78\u2010year\u2010old man with a history of ESKD managed with thrice weekly in\u2010center hemodialysis who had a prolonged episode of left elbow pain and drainage and was eventually found to have a skin and soft tissue infection from <jats:italic>Actinomyces radingae<\/jats:italic>. We review the bacteriology of <jats:italic>Actinomyces<\/jats:italic> spp. and the experiences of other providers who have treated actinomycosis in individuals with ESKD. The anatomic sites and demographics of these individuals are heterogeneous, but they all generally require a long antibiotic course with a beta\u2010lactam and portend to a good prognosis. High index of suspicion is needed to identify rare and atypical infections in the ESKD population.<\/jats:p>","DOI":"10.1111\/hdi.12843","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:37:58Z","timestamp":1590557878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A rare case of Actinomyces skin and soft tissue infection in an end\u2010stage kidney disease patient with a review of the literature"],"prefix":"10.1111","volume":"24","author":[{"given":"Leon","family":"Hsueh","sequence":"first","affiliation":[{"name":"Department of Medicine, Veterans Affairs Medical Center  Providence RI USA"},{"name":"Warren Alpert Medical School of Brown University  Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumanth","family":"Kacharam","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University  Providence RI 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