{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T18:09:14Z","timestamp":1748369354844},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ18H050006"],"award-info":[{"award-number":["LQ18H050006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the correlation between serum ectonucleotide pyrophosphatase\/phosphodiesterase\u20101 (ENPP1) level and severity of abdominal vascular calcification in end\u2010stage renal disease (ESRD) patients receiving dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 124 patients were consecutively enrolled into the study in our local institution. Based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines and recommendations, abdomen lateral X\u2010ray was used to determine abdominal aortic calcification score (AACS) for each patient at enrollment. Patients were divided into three groups based on AACS: no or mild calcification group, moderate calcification group, and severe calcification group. The relationships between ENPP1 levels and AACS were assessed by Spearman analysis and the value of ENPP1 in predicting severity of abdominal aortic calcification was evaluated by receiver operating characteristic (ROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of ENPP1 in dialysis patients was (7.68\u2009\u00b1\u20091.67) ng\/ml. There was no significant difference in serum ENPP1 level between peritoneal dialysis patients and hemodialysis patients (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The AACS of dialysis patients was negatively correlated with ENPP1 value (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.70). Compared to no\/mild calcification patients, the levels of serum ENPP1 in patients with moderate\/severe calcification were decreased significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The severity of vascular calcification was correlated with serum ENPP1 value, the severer the vascular calcification, the lower the serum ENPP1 level, and the difference was statistically significant (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The area under ROC curve of ENPP1 was 0.90, the corresponding sensitivity was 0.86, and the specificity was 0.87.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levels of serum ENPP1 in non\u2010diabetic ESRD patients are negatively related to the severity of abdominal aortic vascular calcification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12969","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T06:14:23Z","timestamp":1625724863000},"page":"23-29","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Levels of serum ecto\u2010nucleotide pyrophosphatase\/phosphodiesterase 1 (ENPP1) predicts severity of abdominal aortic calcification in end\u2010stage renal disease patients receiving regular dialysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiujuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuijuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)  Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/14215"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.039"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"S2","article-title":"Incidence, prevalence, and treatment of end\u2010stage renal disease in the Middle East","volume":"16","author":"Abboud O","year":"2006","journal-title":"Ethn Dis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy175"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2020.02.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2019.11.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800709"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ-2004-0465_COR"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01020.2010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3281e386c9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.01.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm566"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00106-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000380966"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01327.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.1.C1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-005-5304-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2350\/07-06-0297.1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.26"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.02.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004080694"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05120610"},{"key":"e_1_2_8_25_1","first-page":"899","article-title":"The relationship between abdominal aortic calcification and the prognosis of maintenance hemodialysis patients[J]","volume":"32","author":"Wang Z","year":"2016","journal-title":"Chinese J Nephrol"},{"key":"e_1_2_8_26_1","first-page":"189","article-title":"The value of abdominal aortic calcification score in predicting the prognosis of cardiovascular and cerebrovascular prognosis in peritoneal dialysis patients","volume":"36","author":"Ma DH","year":"2020","journal-title":"Chinese J Nephrol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.194"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2018.057"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2008.23.3.459"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0353-x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0787-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1336"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.01.033"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03670807"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1690651"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14268"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(03)00058-9"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.12969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:43:00Z","timestamp":1693201380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hdi.12969"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12969","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]},"assertion":[{"value":"2021-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}