{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:55:33Z","timestamp":1766087733665},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK096007\u201001A1","P30DK079328"],"award-info":[{"award-number":["K23DK096007\u201001A1","P30DK079328"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX002009\u201001"],"award-info":[{"award-number":["CX002009\u201001"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Extracellular volume (ECV) predicts mortality in hemodialysis patients, but it is difficult to assess clinically. Peridialytic blood pressure (BP) measurements can help ECV assessment. Orthostatic BP is routinely measured clinically, but its association with ECV is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cohort of hypertensive hemodialysis patients, we measured posthemodialysis ECV\/weight with bioimpedance spectroscopy and analyzed its association with post\u2010HD orthostatic BP measurements obtained during routine care. Using linear and logistic regression, the primary outcomes were orthostatic BP change and orthostatic hypotension (OH) defined by systolic BP decrease of at least 20\u2009mmHg or diastolic decrease of at least 10\u2009mmHg. Model 1 controlled for sex, age, and diabetes. Model 2 additionally controlled for ultrafiltration rate and antihypertensive medications. We conducted sensitivity analysis using OH definition of systolic BP decrease of at least 30\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Among 57 participants, mean orthostatic systolic BP change was \u22127.30 (20) mmHg and mean ECV\/weight was 0.24 (0.04) L\/kg. Post\u2010HD ECV\/weight was not associated with orthostatic systolic BP change (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a08.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.6). There were 16 participants with and 41 participants without OH. The ECV\/weight did not differ between these groups (0.22 [0.04] vs. 0.24 [0.05] L\/Kg, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.09) and did not predict OH in logistic regression (OR 11, 4.04; 95% CI 0.2\u2013671, 0.03\u20130.530 in the two models.) In a sensitivity analysis, ECV\/weight was lower in the OH group (0.22 [0.03] vs. 0.25 [0.04] L\/kg, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), but this was accompanied by differences in sex and diabetes. Using logistic regression, there was no independent association between ECV\/weight with OH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Orthostatic systolic BP change after HD completion is not a reliable indicator of posthemodialysis ECV. When considering other factors associated with orthostatic BP, ECV\/weight is not independently associated with OH. Although transient postdialytic differences in <jats:italic>intravascular<\/jats:italic> volume may be associated with OH, posthemodialysis OH does not necessarily indicate ECV depletion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12979","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T07:29:01Z","timestamp":1629098941000},"page":"124-133","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The associations between orthostatic blood pressure changes and extracellular volume in hemodialysis patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Haekyung","family":"Jeon\u2010Slaughter","sequence":"first","affiliation":[{"name":"Dallas Veterans Affairs Medical Center  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine, Division of Cardiology  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile Parker","family":"Gregg","sequence":"additional","affiliation":[{"name":"Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Division of Nephrology, Department of Medicine Michael E. DeBakey VA Medical Center  Houston Texas USA"},{"name":"VA Health Services Research and Development Center for Innovations in Quality, Effectiveness and Safety  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Dallas Veterans Affairs Medical Center  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine, Section of Nephrology  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Lederer","sequence":"additional","affiliation":[{"name":"Dallas Veterans Affairs Medical Center  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine, Section of Nephrology  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Penfield","sequence":"additional","affiliation":[{"name":"Dallas Veterans Affairs Medical Center  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine, Section of Nephrology  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Noel","family":"Van Buren","sequence":"additional","affiliation":[{"name":"Dallas Veterans Affairs Medical Center  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine, Section of Nephrology  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.276"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000450565"},{"key":"e_1_2_8_5_1","first-page":"120","article-title":"Assessing extracellular volume in hemodiaylsis patients using intradialytic blood pressure slopes","volume":"139","author":"Liu H","year":"2018","journal-title":"Nephron Clin Pract"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020222"},{"key":"e_1_2_8_7_1","unstructured":"With Intradialytic Hypertension. 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Bethesda (MD): National Library of Medicine (US). 2000\u2010[cited January 16 2016] Available fromhttps:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01862497?term=van+buren&rank=2; NLM identifier NCT01862497 NIoDaDaKDNTUoTSMCaDMaToIABPiP"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2011.02.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00812.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh614"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0236-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08240718"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.125674"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq210"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy286"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121053"},{"key":"e_1_2_8_17_1","first-page":"1643","article-title":"Hemodynamic response to fluid removal during hemodialysis: categorization of causes of intradialytic hypotension","volume":"33","author":"Levin N","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.08.024"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09460912"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.383"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00366-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz289"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.237"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.12979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.12979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:43:07Z","timestamp":1693201387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.12979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hdi.12979"],"URL":"https:\/\/doi.org\/10.1111\/hdi.12979","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]},"assertion":[{"value":"2021-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}