{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:36:57Z","timestamp":1789004217980,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["65241"],"award-info":[{"award-number":["65241"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease\u20102019 (COVID\u201019)\u2010related organ failure is partly related to a sepsis\u2010like syndrome and extreme pro\u2010inflammatory cytokine release, named cytokine storm. Therapeutic strategies that prevent the production of or remove the pro\u2010inflammatory cytokines could potentially be an effective therapy in critically afflicted COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this clinical trial study, from April until June 2020, 68 COVID\u201019 patients (35 vs. 33 controls) with severe critical symptoms, and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (P\/F) ratio less than 200\u2009mmHg either received a single standard therapy or a combination of standard treatment for COVID\u201019 combined with hemoperfusion (hemofilter, HA330 D Javfron) for 4\u2009h, in 3 consecutive days. The length of hospital stay and mechanical ventilation, the resolution of radiologic abnormalities, and the mortality rate were defined as the primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographic characteristics, the acute physiology, and chronic health evaluation score of both groups were similar (<jats:italic>p<\/jats:italic>\u00a0&gt;\u20090.05). Importantly, we noticed a significant mortality rate reduction in the perfused group compared with controls (37.1% vs. 63.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), this positive effect was stronger among those with a P\/F ratio higher than 75 (mortality rate of 84.7% for P\/F ratio\u2009&lt;\u200975 vs. 15.4% for P\/F ratio\u2009\u2265\u200975, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results imply that early start of hemoperfusion could be more effective and significantly reduce the mortality rate among COVID\u201019 patients with critical diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.12982","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T04:38:58Z","timestamp":1639543138000},"page":"176-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The early start of hemoperfusion decreases the mortality rate among severe <scp>COVID<\/scp>\u201019 patients: A preliminary study"],"prefix":"10.1111","volume":"26","author":[{"given":"Haleh","family":"Mikaeili","sequence":"first","affiliation":[{"name":"Tuberculosis and Lung Disease Research Center Faculty of Medicine, Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Taghizadieh","sequence":"additional","affiliation":[{"name":"Tuberculosis and Lung Disease Research Center Faculty of Medicine, Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Nazemiyeh","sequence":"additional","affiliation":[{"name":"Tuberculosis and Lung Disease Research Center Faculty of Medicine, Tabriz University of Medical Sciences  Tabriz 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