{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:12Z","timestamp":1791229572899,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015699","name":"Fresenius Medical Care North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In maintenance hemodialysis (HD) patients, low central venous oxygen saturation (ScvO<jats:sub>2<\/jats:sub>) and small decline in relative blood volume (RBV) have been associated with adverse outcomes. Here we explore the joint association between ScvO<jats:sub>2<\/jats:sub> and RBV change in relation to all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study in maintenance HD patients with central venous catheters as vascular access. During a 6\u2010month baseline period, Crit\u2010Line (Fresenius Medical Care, Waltham, MA) was used to measure continuously intradialytic ScvO<jats:sub>2<\/jats:sub> and hematocrit\u2010based RBV. We defined four groups per median change of RBV and median ScvO<jats:sub>2<\/jats:sub>. Patients with ScvO<jats:sub>2<\/jats:sub> above median and RBV change below median were defined as reference. Follow\u2010up period was 3 years. We constructed Cox proportional hazards model with adjustment for age, diabetes, and dialysis vintage to assess the association between ScvO<jats:sub>2<\/jats:sub> and RBV and all\u2010cause mortality during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Baseline comprised 5231 dialysis sessions in 216 patients. The median RBV change was \u22125.5% and median ScvO<jats:sub>2<\/jats:sub> was 58.8%. During follow\u2010up, 44 patients (20.4%) died. In the adjusted model, all\u2010cause mortality was highest in patients with ScvO<jats:sub>2<\/jats:sub> below median and RBV change above median (HR 6.32; 95% confidence interval [CI] 1.37\u201329.06), followed by patients with ScvO<jats:sub>2<\/jats:sub> below median and RBV change below median (HR 5.04; 95% CI 1.14\u201322.35), and ScvO<jats:sub>2<\/jats:sub> above median and RBV change above median (HR 4.52; 95% CI 0.95\u201321.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Concurrent combined monitoring of intradialytic ScvO<jats:sub>2<\/jats:sub> and RBV change may provide additional insights into a patient's circulatory status. Patients with low ScvO<jats:sub>2<\/jats:sub> and small changes in RBV may represent a specifically vulnerable group of patients at particularly high risk for adverse outcomes, possibly related to poor cardiac reserve and fluid overload.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13104","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T06:49:56Z","timestamp":1686638996000},"page":"278-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interactions between intradialytic central venous oxygen saturation, relative blood volume, and all\u2010cause mortality in maintenance hemodialysis patients"],"prefix":"10.1111","volume":"27","author":[{"given":"Priscila","family":"Preciado","sequence":"first","affiliation":[{"name":"Renal Research Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rosales 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