{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:50:21Z","timestamp":1774374621263,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004915","name":"Nyreforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fluid overload is a major challenge in hemodialysis patients and might cause hypervolemia. We speculated that hemodialysis patients reaching dry weight could have undetected hypervolemia and low hemoglobin (Hb) concentration (g\/dL) due to hemodilution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included hemodialysis patients (<jats:italic>n<\/jats:italic>\u2009=\u200922) and matched healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200922). Blood volume, plasma volume, red blood cell volume, and total Hb mass were determined using a carbon monoxide (CO)\u2010rebreathing method in hemodialysis patients reaching dry weight and controls. Blood volume measurements were also obtained by a dual\u2010isotope labeling technique in a subgroup for validation purposes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>In the hemodialysis group, the median specific blood volume was 89.3\u2009mL\/kg (interquartile range [IQR]: 76.7\u201395.4\u2009mL\/kg) and was higher than in the control group (79.9\u2009mL\/kg [IQR: 70.4\u201388.0\u2009mL\/kg]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.037). The median specific plasma volume was 54.7\u2009mL\/kg (IQR: 47.1\u201361.0\u2009mL\/kg) and 44.0\u2009mL\/kg (IQR: 38.7\u201349.5\u2009mL\/kg) in the hemodialysis and control groups, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Hb concentration was lower in hemodialysis patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas no difference in total Hb mass was observed between groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.11). A correlation was found between blood volume measured by the CO\u2010rebreathing test and the dual\u2010isotope labeling technique in the control group (<jats:italic>r<\/jats:italic>\u2009=\u20090.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.015), but not the hemodialysis group (<jats:italic>r<\/jats:italic>\u2009=\u20090.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The hemodialysis group had increased specific blood volume at dry weight due to high plasma volume, suggesting a hypervolemic state. However, correlation was not established against the dual\u2010isotope labeling technique underlining that the precision of the CO\u2010rebreathing test should be further validated. The total Hb mass was similar between hemodialysis patients and controls, unlike Hb concentration, which emphasizes that Hb concentration is an inaccurate marker of anemia among hemodialysis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13118","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T02:06:09Z","timestamp":1697162769000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravascular volumes and the influence on anemia assessed by a carbon monoxide rebreathing method in patients undergoing maintenance hemodialysis"],"prefix":"10.1111","volume":"28","author":[{"given":"V\u00e5rin","family":"Vinje","sequence":"first","affiliation":[{"name":"Department of Nephrology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-4761","authenticated-orcid":false,"given":"Tobias","family":"Bomholt","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Lundby","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"},{"name":"Section for Health and Exercise Physiology, Faculty of Social and Health Sciences Inland Norway University of Applied Sciences  Lillehammer Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oturai","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Rix","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Lindhard","sequence":"additional","affiliation":[{"name":"Department of Nephrology Herlev Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Hornum","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V102392"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016121341"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn707"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.807362"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr678"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000086"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1711-6"},{"issue":"8","key":"e_1_2_9_10_1","first-page":"793","article-title":"Recommended methods for measurement of red\u2010cell and plasma volume: International Committee for Standardization in Haematology","volume":"21","author":"No authors listed","year":"1980","journal-title":"J Nucl Med"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000082998.50730.FA"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12952"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368157"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345484"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00880207"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1471-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1473-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.67"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.12.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/35\/2\/n11"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000729"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.2.623"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.589008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198911000-00020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00185.2017"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1900.sp000800"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01603"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.169680"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018851"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12776"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg355"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2681-0"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2020.1818282"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2023.03.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12881"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0826-9235"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365519109091106"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2016.1271908"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13900"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.13118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T07:21:57Z","timestamp":1705908117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.13118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/hdi.13118"],"URL":"https:\/\/doi.org\/10.1111\/hdi.13118","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"2023-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}