{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:44:27Z","timestamp":1777081467145,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anemia and vitamin D deficiency are common problems among hemodialysis (HD) patients. This study aimed to assess the impact of correction of vitamin D deficiency with vitamin D supplementation on the improvement of anemia in patients with end\u2010stage renal disease (ESRD) on maintenance HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind, randomized, controlled study included 100 anemic HD patients with vitamin D deficiency who were randomly divided using the closed envelop method into two groups (1:1). The first group received vitamin D (50,000\u2009IU) monthly for 6\u2009months, and the other group received a placebo for the same period. 25\u2010Hydroxyvitamin D (25(OH)D) levels were measured for both groups at the beginning of the study and after 6\u2009months at the end of the study. Hemoglobin (Hb) concentrations were recorded monthly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Vitamin D supplementation during the period of the study increased 25(OH)D levels in the vitamin D group more than the placebo group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.001). Serum ferritin, serum iron, and transferrin saturation did not differ significantly between both groups during the period of the study. Hb concentration in the vitamin D group increased more than that in the other group over the period of the study, and there was a statistically significant difference between the two groups in all durations of follow\u2010up. Erythropoietin (EPO) dosage requirements were found to be lower in the vitamin D group than in the placebo group, and this was statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Vitamin D supplementation in anemic ESRD patients on HD with vitamin D deficiency or insufficiency is safe and effective in improving anemia and decreasing EPO dosage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13121","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T03:27:15Z","timestamp":1697686035000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of vitamin D supplementation on management of anemia in hemodialysis patients with vitamin D deficiency: A double\u2010blind, randomized, controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Sameh Mohamed","family":"Emarah","sequence":"first","affiliation":[{"name":"Department of Nephrology Armed Forces Hospital  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abd El Rahman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Medical Military Academy  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada Mohamed","family":"El Kannishy","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-2404","authenticated-orcid":false,"given":"Ahmed Elsaeed","family":"Abdulgalil","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321521"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005090997"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000852020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040328"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00186.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15081773"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/679619"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.139"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.551"},{"key":"e_1_2_10_12_1","first-page":"279","article-title":"KDIGO 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