{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:06:17Z","timestamp":1790834777920,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intradialytic exercise is essential for improving physical function for older patients. This study aimed to examine the relationship between the effects of exercise therapy and aging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter cohort study included 1176 patients aged 40\u201389\u2009years, who participated in an intradialytic exercise program, comprising stretching and resistance training, three times per week for 12\u2009months. Isometric knee extension strength (IKES), 10\u2010m walking speed, Short Physical Performance Battery (SPPB), and Geriatric Nutritional Risk Index (GNRI) were measured at baseline and after 12\u2009months. The patients were divided according to age as follows: 40\u201359, 60\u201369, 70\u201379, and 80\u201389\u2009years. A linear mixed\u2010effects model examined the improvement within\u2010group and between\u2010control differences, as the 40\u201359 age group was the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The 40\u201359, 60\u201369, 70\u201379, and 80\u201389 age groups comprised 180, 317, 466, and 213 participants, respectively. Within\u2010group differences, all the age groups significantly improved IKES and SPPB. The 10\u2010m walking speed [0.02 (0.02) m\/s] and GNRI [0.38 (0.33)] did not improved only in the 80\u201389 age group despite other age groups significantly improved. Between\u2010control differences, IKES of the 70\u201379 age group [\u22120.24 (\u22120.42 to \u22120.06) %] was significantly lower improvement than control. GNRI of all the older groups were significantly smaller improvement than control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The older group demonstrated difficulty in improving walking ability and nutritional status compared with the younger groups. Clinicians need to consider the difference in effectiveness due to age and prescribe intradialytic exercises accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13128","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T03:45:15Z","timestamp":1699415115000},"page":"117-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Age\u2010associated effects of intradialytic exercise on physical function and nutritional status in patients receiving ambulatory hemodialysis: A multicenter cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-7352","authenticated-orcid":false,"given":"Ren","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Kaikoukai Josai Hospital  Nagoya Aichi Japan"},{"name":"Division of Rehabilitation Science Seirei Christopher University Graduate School  Hamamatsu Shizuoka 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