{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:21:30Z","timestamp":1762100490960,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sacubitril\/valsartan is increasingly used in hemodialysis patients due to its cardioprotective benefits. However, its impact on serum potassium levels in anuric patients undergoing hemodialysis remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective data from patients undergoing hemodialysis at two dialysis centers. A total of 71 out of 332 patients receiving hemodialysis treatment were enrolled. Mean serum potassium (mean value of 6\u20138 determinations), peak serum potassium (maximum K value observed during follow\u2010up observations), and other biochemical parameters were recorded at baseline and during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>After 6\u2009months of follow\u2010up, mean serum potassium increased from 4.84\u2009\u00b1\u20090.45\u2009mmol\/L at baseline to 5.07\u2009\u00b1\u20090.46\u2009mmol\/L at 3\u2009months and 5.04\u2009\u00b1\u20090.46\u2009mmol\/L at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Notably, no significant group differences were found in peak serum potassium concentrations between baseline and 6\u2009months after sacubitril\/valsartan therapy (5.69\u2009\u00b1\u20090.56 vs. 5.75\u2009\u00b1\u20090.41, <jats:italic>p<\/jats:italic>\u2009=\u20090.419). Prior to starting sacubitril\/valsartan treatment, none of the patients had severe hyperkalemia; however, after 3 and 6\u2009months of sacubitril\/valsartan therapy, two (2.80%) and three (4.20%) patients experienced severe hyperkalemia, respectively; however, this difference was not statistically significant. Additionally, there was a significant reduction in blood pressure; however, serum sodium, bicarbonate, and Kt\/V values did not change significantly during either period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Sacubitril\/valsartan therapy is associated with an increase in serum potassium levels in anuric hemodialysis patients. Nevertheless, the proportion of patients with severe hyperkalemia did not increase significantly. This suggests that the use of sacubitril\/valsartan in anuric patients on hemodialysis is relatively safe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13150","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:54:22Z","timestamp":1711958062000},"page":"336-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence of hyperkalemia in anuric hemodialysis patients treated with sacubitril\/valsartan"],"prefix":"10.1111","volume":"28","author":[{"given":"Xiaofan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology Peking University Shougang Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Blood Purification Center Chifeng Municipal Hospital  Chifeng 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